4,6,7) These may harbour chronically activated B-cells
that could act as APC, as regulators of local immune responses and as potential precursors of immunoglobulin (Ig)secreting plasma cells within the CNS compartment.
Poster 536 - Chemotherapy-Refractory Diffuse Large B-Cell
Lymphomas (DLBCL) Are Effectively Killed by Ofatumumab-Induced Complement-Mediated Cytoxicity
Extensive clinical studies of ZEVALIN have confirmed high response rates and durable responses in patients with relapsed, refractory follicular or transformed B-cell
Learning of this, Edwards forged ahead with testing B-cell
depletion in 20 people who have had rheumatoid arthritis for an average of 22 years and have failed to respond to conventional drugs.
The solution is to turn everything off and start up afresh - which in this case means using drugs to eliminate all the B-cells
GA101 has been specifically designed as the first glycoengineered, type 2 anti-CD20 monoclonal antibody in development for B-cell
The incidence is 8,100 to 12,500 new cases in the US per year and 85-95% of the cases are of B-cell
In 1997, Rituxan was the first monoclonal antibody approved for cancer, when it was approved for treating relapsed or refractory low-grade or follicular CD20-positive, B-cell
Masayuki Noguchi, who works with Leonard, studied IL-7, which typically stimulates the growth of immature T-cells in the thymus and affects the development of a different white cell, the B-cell
Non-progressing (including stable disease), low-grade, CD20-positive, B-cell
NHL as a single agent after first-line CVP chemotherapy
, as well as islet clusters with lower than normal amount of non b-cells
, do not release insulin in this biphasic manner, with no fine-tuning for intermediate concentrations of glucose in the blood.
HuMax-CD20 is a human antibody which is effective at binding to the CD20 molecule on B-cells