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B-cell lymphoproliferative syndrome

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B-cell lymphoproliferative syndrome
An uncommon, life-threatening complication of BM or organ transplantation caused by profound immunosuppression, which may be induced by EBV; BLS occurs in < 0.5% of the recipients of HLA-identical BM, but is common in Pts who suffered severe GVHD and were treated with anti-CD3 antibodies Clinical Ranges from self-limited, spontaneously-resolving infectious mononucleosis to oligoclonal or monoclonal proliferations and aggressive lymphomas Prognosis 80-90% mortality in BM recipients; 60% survival in those receiving other organs. See EBV-related associated lymphoproliferative disorder.


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