cyanocobalamin

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cyanocobalamin

 [si″ah-no-ko-bal´ah-min]
vitamin B12, a substance having hematopoietic activity found in liver, fish meal, eggs, and other natural sources, or produced from cultures of Streptomyces griseus; it combines with intrinsic factor for absorption and is needed for erythrocyte maturation. Absence of intrinsic factor leads to malabsorption of cyanocobalamin and results in pernicious anemia. Called also extrinsic factor. See also vitamin.
cyanocobalamin Co-57 a radiopharmaceutical used in the schilling test for the diagnosis of pernicious anemia.

cy·a·no·co·bal·a·min

(sī'an-ō-kō-bal'ă-min),
A complex of cyanide and cobalamin, as in vitamin B12, in which a cyanide group has filled the sixth coordinate position of the cobalt atom.

cyanocobalamin

/cy·a·no·co·bal·a·min/ (-ko-bal´ah-min) a cobalamin in which the substituent is a cyanide ion; it is the form of vitamin B12 first isolated and, although an artifact, is used to denote the vitamin; preparations are used to treat vitamin-associated deficiencies, particularly pernicious anemia and other megaloblastic anemias.

cyanocobalamin

(sī′ə-nō′kō-băl′ə-mĭn, sī-ăn′ō-)

cyanocobalamin

[sī′ənōkōbal′əmin]
Etymology: Gk, kyanos + Ger, kobald, mine goblin
a red crystalline, water-soluble substance that is the common pharmaceutic form of vitamin B12. It is involved in the metabolism of protein, fats, and carbohydrates; normal blood formation; and neural function. It is the first substance containing cobalt found to be vital to life. It cannot be produced synthetically but can be obtained from cultures of Streptomyces griseus. Rich dietary sources are liver, kidney, meats, fish, and dairy products. Deficiency can be caused by the absence of intrinsic factor (produced in the stomach), which is necessary for the absorption of cyanocobalamin from the GI tract. Deficiency can also occur in persons whose diet is strictly vegetarian, thereby excluding meat and dairy sources of the nutrient. Symptoms of deficiency include nervousness, neuritis, numbness and tingling in the hands and feet, poor muscular coordination, and menstrual disturbances. Cyanocobalamin (via injection) is used in the prophylaxis and treatment of pernicious anemia, tropical and nontropical sprue, and other macrocytic and megaloblastic anemias. It is relatively nontoxic, even when administered in amounts greater than those recommended for therapeutic purposes. Also called antipernicious anemia factor, vitamin B12, extrinsic factor. See also intrinsic factor, pernicious anemia.

vitamin B12

A water-soluble vitamin of animal origin required for DNA synthesis. It is a glycoprotein produced and secreted by the gastric parietal cells, and is absorbed from the GI tract bound to intrinsic factor; the body stores up to one years’ worth of vitamin B12 in the liver, kidneys and heart. Rapid cell turnover (e.g., growth spurts in children, malignancy) require increased amounts of vitamin B12. Vegans, who ingest no protein of animal origin, are at risk for vitamin B12 deficiency.

Increased by
Chronic myeloid leukaemia, chronic obstructive pulmonary disease, congestive heart failure, liver disease, obesity, polycythemia vera, renal failure.
 
Decreased by
Atrophic gastritis, drugs (antibiotics, anticonvulsants, antimalarials, antituberculous agents, chemotherapy, contraceptives, diuretics, oral hypoglycemics, sedatives), inflammatory bowel disease (e.g., Crohn’s disease, ulcerative colitis), intrinsic factor deficiency (causing megaloblastic anaemia), malabsorption, malnutrition, parasites (e.g., Diphyllobotrium latum), veganism.

cyanocobalamin

Vitamin B12 A water soluble B vitamin, central to proper CNS function, and carbohydrate, protein and fat metabolism. See Vitamin B12.

cy·a·no·co·bal·a·min

(sī'ă-nō-kō-bal'ă-min)
A complex of cyanide and cobalamin, as in vitamin B12.

cyanocobalamin

Vitamin B12. This vitamin is necessary for the normal metabolism of carbohydrates, fats and proteins, for blood cell formation and for nerve function. It is used in the treatment of PERNICIOUS ANAEMIA and SPRUE. Brand names are Cytacon and Cytamen.

cyanocobalamin

see COBALAMIN.

cyanocobalamin

vitamin B12; haemopoietic agent used to treat pernicious anaemia

cyanocobalamin (sīˈ··nōˈ·kō·baˑ·l·mn),

n See vitamin B12.

cy·a·no·co·bal·a·min

(sī'ă-nō-kō-bal'ă-min)
A complex of cyanide and cobalamin, as in vitamin B12.

cyanocobalamin (sī´ənō´kōbal´əmin),

n (vitamin B12),
brand names (some): Alpha Redisol, Betalin-12, Cobex;
drug class: Vitamin B12 water-soluble vitamin;
action: needed for adequate nerve functioning, protein and carbohydrate metabolism, normal growth, red blood cell development, and cell reproduction;
uses: vitamin B12 deficiency, pernicious anemia, hemolytic anemia, hemorrhage, and renal and hepatic diseases.

cyanocobalamin

Patient discussion about cyanocobalamin

Q. Can a food rich in vitamin B12 will help for his depression or vitamin B12 pills are always required? Hi all…..having one question related to my friends depression and its relation to vitamin B12, as a medicine given to him by his Doctor. Can a food rich in vitamin B12 will help for his depression or vitamin B12 pills are always required?

A. Yes low level of vitamin B12 is associated with depression. You can complete its deficiency by having good diet which will cover the B12 requirements. What happens that depressed people tend to eat less of healthy food and which reduces the B12. So, it again reduces the capacity to fight against the depression.

More discussions about cyanocobalamin
References in periodicals archive ?
Those who had higher blood folate levels and higher B-12 levels were twice as likely to have a live birth than those with lower levels.
However, a small but statistically significant number - about 4 percent - were found to use alternative treatments classified by the study as potentially unsafe, invasive or unproven, such as antifungal medications, chelation therapy and vitamin B-12 injections.
The management strategy of the adult patient in our report was planned by considering existing B-12 deficiency and the operation performed subsequently, a total gastrectomy.
B-12 for injection is also available by prescription.
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It is recommended to add B-12 when taking high doses of B-9; they can hide B-12 insufficiency.
If high folic acid aggravates vitamin B-12 deficiency what should be done about it?
A safer, more accurate test for vitamin B-12 deficiency--which affects about 1,000,000 Americans over the age of 65--has been developed by researchers at the University of California, Davis.
Now in a newly updated and expanded fourth edition, Simply Vegan: Quick Vegetarian Meals includes information about Protein, Fat, Calcium, Iron, Vitamin B-12, Sources of Omega-3 Fats, Weight Loss, and more.
Some people report relief from vision problems after taking vitamin B-12 shots.
Levels are kept at a healthy minimum by ensuring that your diet contains sufficient amounts of vitamins B-9 (folic acid), B-12 and B-6, maintaining a healthy body weight, remaining physically active, eating plenty of fiber, managing hypertension and limiting alcohol consumption.