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azole
(redirected from Azoles)

    Also found in: Encyclopedia, Wikipedia 0.01 sec.
az·ole (zl, zl)
n.
A class of organic compounds having a five-membered heterocyclic ring with two double bonds; pyrrole.
azole
Infectious disease One of a family of synthetic broad-spectrum antifungal antibiotics–including ketoconazole, fluconazole, itraconazole Indications Various azoles have established efficacy in treating blastomyocosis, candidiasis, coccidioidomycosis, cryptococcosis, histoplasmosis, paracoccidoidomycosis and sporotrichosis Adverse effects N&V, anorexia, rash, pruritus, nonspecific ↑ liver enzymes, anemia, leukopenia, thrombocytopenia, headache, etc Drug interactions Plasma levels of azoles are ↓ by antacids, H2-receptor antagonists, sucralfate, isoniazid, phenytoin, rifampin. See Fluconazole, Itraconazole, Ketoconazole.


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? Mentioned in ? References in periodicals archive
 
Activities of amphotericin B and antifungal azoles alone and in combination against Pseudallescheria boydii.
Invasive fungal sinusitis caused by Pseudallescheria boydii: case ... by Mims, J. Whitman / Ear, Nose and Throat Journal
Clinical isolates exhibited decreased susceptibility to antifungal drugs, especially azoles.
Aspergillus ustus infections among transplant recipients by Marr, Kieren A. / Emerging Infectious Diseases
This broad use of azoles is based on their inhibition of certain pathways of steroidogenesis by high-affinity binding to the enzymes sterol 14[alpha]-demethylase and aromatase.
Azole fungicides affect mammalian steroidogenesis by inhibiting ... by Schlatter, Josef R. / Environmental Health Perspectives
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