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azelastine

   Also found in: Wikipedia 0.03 sec.
azelastine /azel·as·tine/ (ah-zel´as-tēn″) a topical antihistamine used as the hydrochloride salt in the treatment of seasonal allergic rhinitis and allergic conjunctivitis.
azelastine,
an H1-selective antihistamine that also inhibits leukotriene and platelet activating factor (PAF) synthesis and release.
indications This drug is used to treat seasonal allergic rhinitis and seasonal allergic conjunctivitis.
contraindications Known hypersensitivity, acute asthma attacks, and lower respiratory tract disease prohibit this drug's use.
adverse effects Side effects include sedation (more common with increased doses), increased drowsiness, weight increase, and myalgia.


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The product, 'Higuard', is the first Rx-to-OTC switch product of azelastine hydrochloride, an anti-allergy compound originally approved for prescription use.
The studies focused on the antimuscarinic (potential for drying side effects) activity of various marketed antihistamines including azelastine, cetirizine, desloratadine, fexofenadine, ketotifen and olopatadine, compared to bilastine and epinastine, related compounds in Inspire's portfolio.
 
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