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memantine |
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memantine,
an anti-Alzheimer agent. indications This drug is used to treat moderate to severe dementia in Alzheimer's disease. contraindication Known hypersensitivity to this drug prohibits its use. adverse effects Adverse effects of this drug include somnolence, headache, hallucinations, hypertension, vomiting, constipation, rash, coughing, dyspnea, back pain, fatigue, and pain. Common side effects include dizziness and confusion. memantine Ebixa (UK), Namenda Pharmacologic class: N-methyl-D-aspartate receptor antagonist (NMDA) Therapeutic class: Anti-Alzheimer's agent Pregnancy risk category B ActionUnclear. Thought to act as a low- to moderate-affinity NMDA receptor antagonist, binding to NMDA receptor-operated channels. (Activation of these channels is thought to contribute to Alzheimer's symptoms.) AvailabilityTablets: 5 mg, 10 mg Tablets (titration pack): 28 tablets of 5 mg and 21 tablets of 10 mg ⊘Indications and dosages ➣ Moderate to severe Alzheimer's-type dementia Adults: Initially, 5 mg P.O. daily. Then titrate at intervals of at least 1 week in 5-mg increments, to a maximum of 10 mg P.O. b.i.d. Dosage adjustment• Moderate renal impairment Contraindications• Hypersensitivity to drug or its components PrecautionsUse cautiously in: Administration• Give with or without food.
Adverse reactionsCNS: dizziness, headache, syncope, aggressive reaction, confusion, somnolence, hallucinations, agitation, insomnia, vertigo, ataxia, abnormal gait, hypokinesia, anxiety, transient ischemic attack, cerebrovascular accident (CVA) CV: hypertension, cardiac failure EENT: cataract, conjunctivitis GI: nausea, vomiting, diarrhea, constipation, anorexia GU: frequent voiding, urinary incontinence, urinary tract infection Hematologic: anemia Musculoskeletal: back pain, arthralgia Respiratory: cough, dyspnea, bronchitis, pneumonia Skin: rash Other: weight loss, fatigue, pain, falls, flulike symptoms, peripheral edema InteractionsDrug-drug. Cimetidine, hydrochlorothiazide, nicotine, quinidine, ranitidine, triamterene: altered blood levels of both drugs Urine-alkalizing drugs (carbonic anhydrase inhibitors, sodium bicarbonate): decreased memantine elimination Drug-diagnostic tests. Alkaline phosphatase: increased level Patient monitoring☞ Check for heart failure and signs and symptoms of CVA. Patient teaching• Tell patient to take with or without food. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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Mobius, chief scientific officer of Merz Pharmaceuticals, a Germany company that holds the licensing rights to memantine and also markets the drug as Axura in several countries. Key Topics Covered: * Alzheimer's Disease * Alzheimer's Disease Statistics * The Global Drug Market * Donepezil Hydrochloride (Aricept) * Memantine Axura Namenda Ebixa * Rivastigmine Tartrate (Exelon) * Piracetam Nootropil * Galantamine (Razadyne) * Global and Regional Sales * Other Marketed Therapeutic Agents * Drug Repurposing in Alzheimer's Disease * Drug Pipeline - Phases I-III * Discussion For more information visit http://www. |
Axura |
AXR AXREM AXS AXSD axseed AXSIA AXSIGCOMM Axsinaminshi AxsJAX AXSM Axstone AXT AXTBS AXTP AXTR Axtree AXU Axum Axum Axum Axum stelae Axum stelae Axum, Ethiopia Axum, Ethiopia Axumite Axumite Axumites Axumites Axunge Axura AXVaXway Integration Broker AXX Axxcelera Broadband Wireless Axxess Steering Wheel Control AXXS AXY Axyris AXZ.AX ay ay Ay Dios Mio Ay Que Funny Aya Aya Aya aye Aya aye Aya aye Aya Napa Aya Sofia Aya Sofia Aya Sofya Aya Sofya AYAA Ayabe Ayabe, Kyoto AYAC ayacc Ayacucho Ayacucho | ||||||||
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