nizatidine (redirected from Axid AR)

nizatidine /ni·za·ti·dine/ (nĭ-zat´ĭ-dēn) a histamine H2 receptor antagonist, used to inhibit gastric acid secretion in the treatment of gastric and duodenal ulcer, gastroesophageal reflux disease, and conditions that cause gastric hypersecretion.

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ni·zat·i·dine (n-zt-dn)

n.

A histamine antagonist used in the treatment of active duodenal ulcers.

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nizatidine (nīzat´dēn´),

n brand name: Axid;
drug class: H₂-histamine receptor antagonist;
action: inhibits histamine at H₂ receptor site in parietal cells, which inhibits gastric acid secretion;
uses: duodenal ulcer, Zollinger-Ellison syndrome, gastric ulcers, hypersecretory conditions, gastroesophageal reflux disease, stress ulcers.

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nizatidine

a histamine H₂-receptor antagonist, similar to cimetidine, used to reduce gastric acidity in the treatment of gastrointestinal ulceration.

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nizatidine

Axid, Axid AR

Pharmacologic class: Histamine₂ (H₂)-receptor antagonist

Therapeutic class: Antiulcer drug

Pregnancy risk category B

Action

Inhibits histamine action at H₂-receptor sites in gastric parietal cells, reducing gastric acid secretion and pepsin production

Availability

Capsules: 150 mg, 300 mg

Oral solution: 15 mg/ml

Tablets: 75 mg

⊘Indications and dosages

➣ Active duodenal ulcer

Adults: 300 mg P.O. daily at bedtime or 150 mg b.i.d. for up to 8 weeks

➣ Maintenance of healed duodenal ulcers

Adults and children ages 12 and older: 150 mg P.O. daily at bedtime for up to 1 year

➣ Esophagitis and associated heartburn caused by gastroesophageal reflux disease (GERD)

Adults: 150 mg P.O. b.i.d. for up to 12 weeks

➣ Active benign gastric ulcer

Adults: 150 mg P.O. b.i.d. or 300 mg P.O. once daily at bedtime

➣ Erosive esophagitis; GERD

Children ages 12 and older: 150 mg P.O. b.i.d. for up to 8 weeks

Dosage adjustment

• Moderate to severe renal impairment
• Elderly patients

Contraindications

• Hypersensitivity to drug or other H₂-receptor antagonists

Precautions

Use cautiously in:
• mild renal impairment
• elderly patients
• pregnant or breastfeeding patients
• children younger than age 12 (safety and efficacy not established).

Administration

• Give with or without food.
• If patient is to take drug twice daily, give one dose in morning and one at bedtime.

Route	Onset	Peak	Duration
P.O.	Unknown	0.5-3 hr	8-12 hr

Adverse reactions

CNS: dizziness, drowsiness, headache, anxiety, nervousness, insomnia, abnormal dreams, asthenia

CV: chest pain

EENT: amblyopia, sinusitis, rhinitis, pharyngitis

GI: nausea, vomiting, diarrhea, constipation, dyspepsia, abdominal pain, flatulence, anorexia, dry mouth

Hematologic: anemia

Musculoskeletal: back pain, myalgia

Respiratory: cough

Skin: rash, pruritus

Other: tooth disorder, infection, fever, pain

Interactions

Drug-drug. Salicylates (high doses): increased salicylate blood level

Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase: elevated levels

Urobilinogen tests using Multistix: false-positive result

Drug-herbs. Pennyroyal: altered rate of herbal metabolite formation

Patient monitoring

• Monitor liver and renal function tests.
• Check temperature; watch for fever and other signs and symptoms of infection.

Patient teaching

• Advise patient to take once-daily dose at bedtime with or without food, or twice-daily doses in morning and at bedtime.
• Instruct patient to take exactly as prescribed. Caution him not to take other OTC drugs (especially aspirin).
• Tell patient to report signs and symptoms of infection.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, and herbs mentioned above.

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nizatidine

Axid^® Therapeutics An H₂-receptor antagonist used to treat peptic ulcer disease Adverse reactions Diarrhea, headache, drowsiness, fatigue, muscle pain, constipation, confusion, agranulocytosis, gynecomastia, impotence, allergic reactions, tachycardia, arrhythmias, interstitial nephritis, etc. See Histamine receptor antagonists.