The clinical appearance and genetic basis of familial isolated growth hormone deficiency (IGHD) are heterogeneous and are associated with at least four types of Mendelian disorders: two forms with autosomal recessive inheritance (IGHD type 1A and 1B), one with autosomal dominant inheritance
(IGHD type 2), and one with X-linked inheritance (IGHD type 3) (1, 2).
A disorder derived from mtDNA should be transmitted vertically through a family in a situation resembling autosomal dominant inheritance
with both genders expressing the phenotype, but there should be no instances of father-to-child transmission.
There is usually a VHL tumor suppressor gene germline mutation with an autosomal dominant inheritance
Familial idiopathic brain calcification with autosomal dominant inheritance
Autosomal dominant inheritance
has rarely been reported with familial DCM.
It can be inherited through autosomal dominant inheritance
, in which one gene for the condition expresses itself in an individual; or through autosomal recessive inheritance, in which the recessive (unexpressed) gene is passed from each parent and the two genes are paired together, causing the disorder to be expressed in the child.
According to them, these primary electrical heart disorders are mostly subject to autosomal dominant inheritance
, which means that family members have a 50 per cent risk of being carriers of the modified gene causing the disorder.
Characteristics of autosomal dominant inheritance
of breast cancer
HAE, a rare genetic disorder with autosomal dominant inheritance
, is caused by a deficiency of C1 inhibitor (C1-INH).
Family history of multigenerational breast/ovarian cancers suggestive of autosomal dominant inheritance
In the cases with established family history and autosomal dominant inheritance
SCA1 was most prevalent followed by SCA2 and SCA3.
of the University of Milan, and his colleagues, also detected the mutation in 4 of 61 families (7%) with Parkinson's disease and apparent autosomal dominant inheritance