Autosomal dominant


Also found in: Acronyms.

autosomal dominant

adjective Referring to a trait or disorder that may be passed from one generation to the next when only one allele is required to pass a genetic defect to the progeny.

Examples
Achondroplasia, Huntington’s disease, Marfan syndrome, neurofibromatosis, osteogenesis imperfecta.

autosomal dominant

Genetics Referring to a mode of inheritance, in which the presence of only one copy of a gene of interest on one of the 22 autosomal–non-sex chromosomes, will result in the phenotypic expression of that gene; the likelihood of expressing an autosomal gene in progeny is 1:2; ♂ and ♀ are affected equally. Cf Autosomal recessive, X-linked recessive.

autosomal dominant

Pert. to or characteristic of an autosomal dominant gene.
See: autosomal dominant gene

Autosomal dominant or autosomal recessive

Refers to the inheritance pattern of a gene on a chromosome other than X or Y. Genes are inherited in pairs—one gene from each parent. However, the inheritance may not be equal, and one gene may overshadow the other in determining the final form of the encoded characteristic. The gene that overshadows the other is called the dominant gene; the overshadowed gene is the recessive one.
References in periodicals archive ?
They were previously described as the May-Hegglin anomaly, Fechtner syndrome, Sebastian syndrome, and Epstein syndrome, yet they all result from autosomal dominant mutations in the cytoskeletal protein MYH9.
Autosomal Dominant Polycystic Kidney Disease with multiple extra renal complications including polycystic liver disease, epigastric hernia and pericardial effusion.
White matter pathology and disconnection in the frontal lobe in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
We have found that this phenotype is most frequently inherited in an autosomal dominant manner and that, when this occurs, it is exclusively associated with increased copy number on a single allele of alpha tryptase-encoding sequence in the TPSAB1 gene," a genetic trait they called "hereditary alpha-tryptasemia.
3 Mode of inheritance: Autosomal dominant Syndrome: Muir-Torre syndrome, variant of Lynch syndrome
A diagnosis of autosomal dominant hereditary congenital facial palsy was made.
Tenders are invited for Increase investigator interest in basic and applied investigations of the etiology and pathogenesis of Polycystic Kidney Disease (PKD), in both its autosomal dominant and autosomal recessive forms.
It is usually transmitted by autosomal dominant group of inheritance.
Prevalence of cardiovascular events in patients with autosomal dominant polycystic kidney disease.
Hyper-IgE syndrome with recurrent infections--an autosomal dominant multisystem disorder.
It also provided a definitive diagnosis for the patient's affected family members in this autosomal dominant disorder.

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