autoimmunity

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Related to Autoantigens: Autoimmune reaction

autoimmunity

 [aw″to-ĭ-mu´nĭ-te]
a condition characterized by a specific humoral or cell-mediated immune response against the constituents of the body's own tissues (autoantigens); it may result in hypersensitivity reactions or, if severe, in autoimmune disease.

au·to·im·mu·ni·ty

(aw'tō-i-myū'ni-tē),
In immunology, the condition in which one's own tissues are subject to deleterious effects of actions of the immune system, as in autoallergy and in autoimmune disease; specific humoral or cell-mediated immune response against the body's own tissues. Synonym(s): autoallergy

autoimmunity

/au·to·im·mu·ni·ty/ (-ĭ-mu´nĭ-te) a condition characterized by a specific humoral or cell-mediated immune response against the constituents of the body's own tissues (autoantigens); it may result in hypersensitivity reactions or, if severe, in autoimmune disease.

autoimmunity

[-imyo̅o̅′nitē]
an abnormal condition in which the body reacts against constituents of its own tissues. Autoimmunity may result in hypersensitivity and autoimmune disease. Also called acute immune disease. See also antibody-specific model, autoantibody, autoantigen, autoimmune disease.

autoimmunity

The reaction of a host organism’s immune system to self-antigens as if they were foreign. It is characterised by T-cell activation, clonal expansion and antibody production against tissues, cells and antigens, which results in autoimmune disease.

autoimmunity

Self immunity Immunology The reaction of an organism's immune system to self antigens as if they were non-self or foreign; like alloimmunity, autoimmunity is characterized by the activation of T cells, clonal expansion, and antibody production. See Anti-nuclear antibodies, Anti-receptor antibodies, Clonal anergy, Superantigen.

au·to·im·mu·ni·ty

(aw'tō-i-myū'ni-tē)
immunology The condition in which one's own tissues are subject to deleterious effects of the immune system, as in autoallergy and in autoimmune disease; immune response against the body's own tissues.
See: autoallergy

autoimmunity

a situation where the immunological defences of the body become sensitized to parts of the same body resulting in self-destruction in that area. In other words, ‘self ANTIGENS become mistaken for ‘foreign’ antigens, so setting up an IMMUNE RESPONSE. Such an occurrence is clearly dangerous and may be associated with ageing. An example is rheumatoid arthritis in humans.

Autoimmunity

A condition in which the body's immune system produces antibodies in response to its own tissues or blood components instead of foreign particles or microorganisms.
Mentioned in: AIDS, Hypoparathyroidism

autoimmunity

immunological reaction against self-tissue, to deleterious effect

autoimmunity,

n abnormal immune response where the body attacks its own tissue constituents. Also called
acute immune disease.

au·to·im·mu·ni·ty

(aw'tō-i-myū'ni-tē)
In immunology, the condition in which one's own tissues are subject to deleterious effects of actions of the immune system.

autoimmunity

a condition which may result in autoimmune disease.
References in periodicals archive ?
55) antibody targeting of citrullinated autoantigens.
This may explain in part the disappointing results of recent clinical trials of oral tolerance in patients with type I diabetes, multiple sclerosis, and rheumatoid arthritis, diseases in which there may be multiple target autoantigens that remain largely unknown.
In autoimmune disease, autoantigens can stimulate the differentiation of these induced Treg cells.
25) In this study, disease-specific deposits of IgG or activated complement that correlated with the known distribution of either foreign antigen or autoantigen, were detected in virus-infected cells in progressive multifocal leucoencephalopathy, subacute sclerosing panencephalitis and cytomegalovirus encephalitis; in glial limiting membranes in neuromyelitis optica; and in senile plaques in Alzheimer's dementia.
Postulated candidate autoantigens include insulin, glutamic acid decarboxylase and protein tyrosine phosphatase.
It is designed to induce immunological tolerance of the body's T-cells to key autoantigens involved in the pathogenesis of MS.
The third section of the text discusses type I diabetes mellitus: animal models of type I diabetes mellitus, pancreatic islet cellular autoantigens as they relate to type I diabetes mellitus, and the diagnosis and management of type I diabetes mellitus in humans.
According to this hypothesis, long-term exposure to tobacco smoke can induce the presentation of citrullinated autoantigens in the lungs in genetically predisposed persons, resulting in an activation of the adaptive immune response.
Topics addressing individual predisposition include basic mechanisms in autoimmunity and contributing or environmental factors, autoimmune thyroid disease, including animal models, autoantigens, Grace's Disease, hypothyroidism, postpartum thyroiditis, ophthalmopathy and dermopathy; Type I diabetes mellitus, including animal models, islet cell autoantigens; other autoimmune endocrinopathy's, including Addison's disease, premature ovarian failure, hypophysitis and autoimmune polyglandular syndromes.
AIRE normally plays a role in the thymus in regulating expression of a subset of autoantigens derived from peripheral tissues.
The peptide, now called MBP8298, targets a particular stretch of amino acids of human myelin basic protein (MBP), a major structural protein of myelin that is one of the candidate autoantigens in MS.
The reacting IgG class antibody, which was purified from normal human serum by affinity chromatography on bupleuran 2IIc (a pharmacologically active pectic polysaccharide from the roots of Bupleurum falcatum)-immobilized Sepharose, showed cross-reactivity not only with some other pharmacologically active pectic polysaccharides from other medicinal herbs but also with autoantigens such as single-strand DNA, myosin and tublin from mammals.