autoantibody

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autoantibody

 [aw″to-an´tĭ-bod″e]
an antibody formed in response to, and reacting against, an antigenic constituent of the individual's own tissues.

au·to·an·ti·bod·y

(aw'tō-an'ti-bod-ē),
An antibody that occurs in response to antigenic constituents of the host's tissue (or "self antigen") and reacts with the inciting target tissue.

autoantibody

/au·to·an·ti·body/ (-an´tĭ-bod″e) an antibody formed in response to, and reacting against, an antigenic constituent of one's own tissues.

autoantibody

(ô′tō-ăn′tĭ-bŏd′ē)
n.
An antibody that reacts with the cells, tissues, or native proteins of the individual in which it is produced.

autoantibody

[ô′tō·an′tibod′ē]
Etymology: Gk, autos + anti, against; AS, bodig, body
an immunoglobulin produced by a person that recognizes an antigen on that person's own tissues. Several mechanisms may trigger the production of autoantibodies: an antigen, formed during fetal development and then sequestered, may be released as a result of infection, chemical exposure, or trauma, as occurs in autoimmune thyroiditis, sympathetic uveitis, and aspermia; there may be disorders of immune regulatory or surveillance function; antibodies produced against certain streptococcal antigens during infection may cross-react with myocardial tissue, causing rheumatic heart disease, or with glomerular basement membrane, causing glomerulonephritis; and normal body proteins may be converted to autoantigens by chemicals, infectious organisms, or therapeutic drugs. Some examples of autoantibodies are those found against gastric parietal cells in pernicious anemia, against platelets in autoimmune thrombocytopenia, and against antigens on the surface of erythrocytes in autoimmune hemolytic anemia. There is growing evidence that genetic factors increase the incidence and severity of autoimmune diseases.

autoantibody

Any antibody produced by an organism against one of its own—self-antigens.

Autoantibodies
Examples of autoantibodies and disease associations
• Anti-actin antibodies—coeliac disease.
• Anti-centromere antibodies—CREST syndrome.
• Anti-ganglioside antibodies—acute motor neuronal neuropathy.
• Antimitochondrial antibody—primary biliary cirrhosis.
• Anti-neutrophil cytoplasmic antibody—Wegener’s granulomatosis (in neutrophil cytoplasm).
• Anti-neutrophil cytoplasmic antibody—Churg-Strauss syndrome, microscopic polyangiitis, systemic vasculitides (perinuclear location).
• Anti-nuclear antibodies (e.g., anti-SSA/Ro)—systemic lupus erythematosus.
• Anti-signal recognition peptide—polymyositis.
• Anti-smooth muscle antibody—chronic autoimmune hepatitis.
• Anti-glomerular basement membrane antibodies.
• Anti-parietal cell antibodies, and others.
• Anti-nuclear antibodies (ANA).
• Anti-smooth muscle actin (SMA).
• Anti-liver-kidney-microsomal antibody (LKM), 2 types:
   - Anti-mitochondrial (AMA);
   - Perinuclear antineutrophil cytoplasmic (pANCA).
• Anti-soluble liver antigen (SLA), other autoantibodies.
• ANA and SMAs are known to be positive in AIH, PBC, PSC, HCV, HBV, HDV, NASH, drug-induced hepatitis.

autoantibody

Immunology Any antibody produced by an organism against one of its own–self antigens. See Antibody, Hashimoto's thyroiditis, Lupus erythematosus, Myasthenia gravis, Rheumatoid arthritis.

au·to·an·ti·body

(aw'tō-an'ti-bod-ē)
Antibody occurring in response to antigenic constituents of the host's tissue, and which reacts with the inciting tissue component.

autoantibody

An antibody derived from the immune system, which then acts against body tissues or constituents.

Autoantibody

An antibody produced by the body in reaction to any of its own cells or cell products.

au·to·an·ti·body

(aw'tō-an'ti-bod-ē)
Antibody occurring in response to antigenic constituents of the host's tissue, and which reacts with the inciting tissue component.

autoantibody,

n an immunoglobulin produced by the immune system that is directed against one or more of the host's own proteins. Many autoimmune diseases in humans, most notably lupus erythematosus, are caused by such antibodies.

autoantibody

an antibody formed in response to, and reacting against, an antigenic constituent of the animal's own cells or tissues.
References in periodicals archive ?
For example, 24 cytokines and autoantibodies were used in a screen for RA due to their ability to predict outcomes in response to a tumor necrosis factor (TNF) blocker, etanercept.
10) Hence, in a variety of ways, autoantibodies play central roles in the self-perpetuating mechanisms underlying pathologic autoimmune response.
Anti-basement membrane autoantibodies in patients with anti-epiligrin cicatricial pemphigoid bind the alpha subunit of laminin 5.
In addition to autoantibodies to myelin, RRMS was also characterized by autoantibodies to heat shock proteins (HSPs) that were not observed in PPMS or SPMS.
Use of serum autoantibodies to identify early-stage lung cancer: A significant step forward in early detection.
The presence of one or both of these IgG autoantibodies in the mother increases the risk of neonatal lupus erythematosus (NLE), which can cause rash or changes in blood counts or liver function and, in severe cases, can affect the conduction system of the heart, Dr.
TAA autoantibodies have also demonstrated the potential to detect cancer early, when the chances for successful treatment are greatest.
Alternatively, the leakage may serve as a booster of a previous immunization, which can both increase cTnAAb titers in blood and improve the affinity of formed autoantibodies.
Abnormal findings on nail-fold capillary microscopy and the presence of scleroderma-specific autoantibodies in patients presenting with new-onset Raynaud's phenomenon without overt connective tissue disease are powerful independent predictors of progression to definite scleroderma.
The study was designed to determine if there was a relationship between the level of UV exposure at the onset of the disease and the type of myositis and autoantibodies that people developed.
Such research led to the development of the anti-cyclic citrullinated peptide (anti-CCP) assay, which detects the presence of anti-citrullinated peptide autoantibodies found in the serum of many patients with RA.
Systemic lupus erythematosus (SLE) is a complex disease characterized by the production of autoantibodies and clinical involvement in multiple organ systems.