A cytochemical and ultrastructural study of acute myelomonocytic leukemia exhibiting the pseudo-Chediak-Higashi anomaly of leukemia and "splinter-type" Auer rods
0% Platelets 30 K/[mu]L 150-450 K/[mu]L Differential Neutrophils 3% 33-61% Lymphocytes 10% 25-45% Blasts 87% 0% Nucleated RBC's 2 RBC Morphology Polychromasia WBC Morphology Auer rods present D-Dimer 18.
3), (5) The presence of Auer rods is also a significant clue.
256 Shows PCR ratio expression of PML/RARA transcript Bone Marrow Differential Erythroid precursors (6%) Occasional cells Segmented displaying large neutrophils/bands(1%) Auer rods, abundant Lymphocytes (2%) granules.
Occasional blasts, especially the more mature forms, may contain blunted Auer rods (Figure B).
The myeloid blasts in t(8; 21) AML are large, with abundant basophilic cytoplasm, with perinuclear hofs, occasional to numerous azurophilic granules, and blunted Auer rods.
Hypergranular acute promyelocytic leukemia (APL): The most common morphologic variant of APL, representing approximately 75% of cases, is characterized by bone marrow containing large, abnormal promyelocytes with pleomorphic nucleoi and cytoplasm containing coarse, large granules with abundant Auer rods
, often in bundles.
Morphological tinclings of pathological "clonal" blasts (type II that contain Auer rods
, Pseudo-Chediak-Higashi or other specific inclusions that are not seen in reactive marrow) refer to the diagnosis of RAEB-2 or AML; here again the arbitrary cut-off point of 20% blasts results in a specific diagnosis.
The cells of acute granulocytic leukemia have been reported to contain a variety of inclusions, including Auer rods, "hexagonal" or "light green" crystals, pseudo-Chediak-Higashi granules, Charcot-Leyden crystals, and other unclassified inclusions.
Acute granulocytic leukemia may contain a variety of intracellular inclusions, including Auer rods, hexagonal or light green crystals, pseudo--Chediak-Higashi granules, Charcot-Leyden crystals, and other unclassified inclusions.
The crystalline structures were believed to be reminiscent of Auer rods.
The possibility of extramedullary myeloid cell tumor was entertained on the original small biopsy owing to the resemblance of the inclusions to Auer rods.