Auer rod


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Auer rod

[ou′ər]
Etymology: John Auer, American physiologist, 1875-1948
an abnormal, needle-shaped or round, pink-staining inclusion in the cytoplasm of myeloblasts and promyelocytes in acute myelogenous, promyelocytic, or myelomonocytic leukemia. These inclusions contain enzymes such as acid phosphatase, peroxidase, and esterase and may represent abnormal derivatives of cytoplasmic granules. The finding of Auer rods in stained blood smears helps to differentiate acute myelogenous leukemia from acute lymphoblastic leukemia. Also called Auer body.
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Auer rod

Auer rod

A pink, round or rod-shaped, splinter- or “jackstraw”-like inclusion seen in the cytoplasm of lymphoblasts in immature granulocytes, and occasionally in monocyte precursors in the peripheral circulation of 10% to 30% of patients with acute non-lymphocytic leukaemias and acute promyelocytic leukaemia. ARs correspond to azurophilic granules with dysplastic lysosomes; cells with multiple AR bundles are known as faggot cells.
References in periodicals archive ?
Hutter G, Nowak D, Blau IW, Thiel E: Auer rod like intracytoplasmic inclusions in multiple myeloma.
In one survey, the CAP received the following five different identifications on a hematology slide: segmented neutrophil, Auer rod, toxic granulation, Barr body, and Dohle inclusion body.
A cytochemical and ultrastructural study of acute myelomonocytic leukemia exhibiting the pseudo-Chediak-Higashi anomaly of leukemia and "splinter-type" Auer rods.
0% Platelets 30 K/[mu]L 150-450 K/[mu]L Differential Neutrophils 3% 33-61% Lymphocytes 10% 25-45% Blasts 87% 0% Nucleated RBC's 2 RBC Morphology Polychromasia WBC Morphology Auer rods present D-Dimer 18.
3), (5) The presence of Auer rods is also a significant clue.
Occasional blasts, especially the more mature forms, may contain blunted Auer rods (Figure B).
The myeloid blasts in t(8; 21) AML are large, with abundant basophilic cytoplasm, with perinuclear hofs, occasional to numerous azurophilic granules, and blunted Auer rods.
Hypergranular acute promyelocytic leukemia (APL): The most common morphologic variant of APL, representing approximately 75% of cases, is characterized by bone marrow containing large, abnormal promyelocytes with pleomorphic nucleoi and cytoplasm containing coarse, large granules with abundant Auer rods, often in bundles.
The cells of acute granulocytic leukemia have been reported to contain a variety of inclusions, including Auer rods, "hexagonal" or "light green" crystals, pseudo-Chediak-Higashi granules, Charcot-Leyden crystals, and other unclassified inclusions.
Acute granulocytic leukemia may contain a variety of intracellular inclusions, including Auer rods, hexagonal or light green crystals, pseudo--Chediak-Higashi granules, Charcot-Leyden crystals, and other unclassified inclusions.
Morphological tinclings of pathological "clonal" blasts (type II that contain Auer rods, Pseudo-Chediak-Higashi or other specific inclusions that are not seen in reactive marrow) refer to the diagnosis of RAEB-2 or AML; here again the arbitrary cut-off point of 20% blasts results in a specific diagnosis.
The crystalline structures were believed to be reminiscent of Auer rods.