atypical small acinar proliferation

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atypical small acinar proliferation (prostate)

A small prostate acinus or acini with abnormal or atypical glands that have insufficient cytological or architectural atypia for a definitive diagnosis of cancer. ASAPs are seen in ±5.5% of patients undergoing needle biopsies of the prostate, in whom cancer is identified in 40–50% on subsequent biopsy.
ASAP is probably best managed with active surveillance.
References in periodicals archive ?
Cases falling short of the threshold for the diagnosis of carcinoma are often descriptively diagnosed as atypical small acinar proliferations.
Collagenous micronodules have not been reported in benign glands, benign prostatic hyperplasia, or prostatic intraepithelial neoplasia, but Iczkowski and Bostwick (14) described them in 2% of the cases they had diagnosed as atypical small acinar proliferations.
The presence of glands in a perineural location used to be considered tantamount to a diagnosis of malignancy, (13) but it has been reported with benign acini (39) and in atypical small acinar proliferations as well.
Recommendations: Atypical small acinar proliferation lesions are cancerous until proven otherwise and should undergo repeat biopsy (Grade B recommendation).
Prognostic significance of high grade prostatic intraepithelial neoplasia and atypical small acinar proliferation in the contemporary era.
Subsequent prostate cancer detection in patients with prostatic intraepithelial noeplasia or atypical small acinar proliferation.
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