atypical adenomatous hyperplasia

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atypical adenomatous hyperplasia

Pathology lung
A term of art for what is essentially dysplassia of type-II cells in the lungs, which corresponds to a small but prominent focus of plump cells lining the air spaces. AAH is often an incidental finding in lungs resected for carcinoma, characterised by firm, 1–5-mm diameter white nodules surrounded by a polygon of interstitial fibrosis—hyperchromatic enlarged cuboidal eosinophilic pneumocytes which are neither papillary nor desquamate, sharply demarcated from surrounding lung. Some develop into bronchoalveolar carcinoma, a relatively indolent malignancy and essentially a carcinoma in situ of the lungs.

Pathology prostate
A localised proliferation of small (prostate) acini, which mimics prostate carcinoma, usually lacks cytological atypia, and has basal cells at the transition zone of the prostate. It is distinguished from well-differentiated CA by a relative lack of nuclear or nucleolar enlargement, infrequent crystalloids and a fragmented, but partially intact, basement membrane. AAH is more common in older patients with larger prostates, greater degree of nodular hyperplasia, more cancer and, if malignant, with higher Gleason scores.

Atypical adenomatous hyperplasia

The over-growth of the endometrium. This precancerous condition is estimated to progress to cancer in one third of the cases.
Mentioned in: Endometrial Cancer
References in periodicals archive ?
Atypical adenomatous hyperplasia is a localized, small (usually 0.
Atypical adenomatous hyperplasia of the lung: a clinicopathological study of 118 cases including cases with multiple atypical adenomatous hyperplasia.
Epidermal growth factor receptor gene amplification in atypical adenomatous hyperplasia of the lung.
Verumontanum mucosal gland hyperplasia is associated with atypical adenomatous hyperplasia of the prostate.
Studies of atypical adenomatous hyperplasia led to the theory of a sequence from premalignant adenoma (adenomatous hyperplasia) to preinvasive adenocarcinoma in situ (bronchioloalveolar carcinoma) to invasive adenocarcinoma for peripheral adenocarcinomas of the lung.
Adenosis, or atypical adenomatous hyperplasia, is another common mimicker of prostatic adenocarcinoma on both needle biopsy and transurethral resection specimens.
Atypical adenomatous hyperplasia of the prostate: morphologic criteria for its distinction from well-differentiated carcinoma.
76,77) Atypical adenomatous hyperplasia should probably be considered a dysplastic lesion that may or may not develop into BAC/in situ adenocarcinoma (Figure 3).
Genetic relationship among atypical adenomatous hyperplasia, bronchioloalveolar carcinoma and adenocarcinoma of the lung.
Atypical adenomatous hyperplasia (AAH) is considered to be the adenoma in the adenoma-carcinoma sequence leading to bronchioloalveolar carcinoma (BAC) and invasive adenocarcinoma of the lung.
Atypical adenomatous hyperplasia was present in 66% (21/32) of prostates with VMGH, compared to only 21% (16/78) of prostates without VMGH (P [is less than] .