ataxin

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ataxin

(ă-tăks'in),
An abnormal protein found in spinal cerebellar ataxias as a result of CAG repeat expansions.
[ataxia + -in]
References in periodicals archive ?
The present proposal aims to study the relationships existing between protein structural dynamics and pathological aggregation of the multidomain N-terminal part of the polyglutamine (polyQ) protein ataxin-3.
Various reported substrates of parkin include CDC-rel-1, O-glycosylated a-synuclein, the parkin-associated endothelin-like receptor, the [alpha]-synuclein--binding protein synphilin-1, actin filaments, the poly(Q)expanded mutant of ataxin-3, Huntington disease polyglutamine proteins, the amyloidogenic Alzheimer disease A[beta] 1-42 peptide (amyloid-[beta] peptide 1-42), and a[beta]-tubulin.
Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3?
In each case, antibodies showed that the mutant form of the protein ataxin-3 had formed large masses inside the nuclei of some brain cells.