AATM

(redirected from Ataxia telangiectasia mutated)
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AATM

A checkpoint kinase that transduces genomic stress signals to halt cell cycle progression and promote DNA repair.
References in periodicals archive ?
Caffeine inhibits activation of ataxia telangiectasia mutated (ATM), and ataxia telangiectasia and Rad3 related (ATR) proteins.
The Ataxia Telangiectasia Mutated (ATM) gene is one candidate for such a susceptibility gene.
Notably, approximately 20% of these candidate genes have already been implicated in Mendelian diseases, including disease genes for rare forms of cancer susceptibility, such as the breast cancer susceptibility loci BRCA1 and BRCA2, neurofibromin 1 (NF1), retinoblastoma locus RB1, Wilms tumor locus WT1, and ataxia telangiectasia mutated (ATM).
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