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ASTISHigh Dose Immunoablation & Hematopoietic Stem Cell Transplantation vs Monthly Intravenous Pulse Therapy Cyclophosphomide (CPP) in Severe Systemic Sclerosis. A scleroderma therapeutic trial comparing the safety and efficacy of 2 different cyclophosphamide (CPP)-based therapeutic strategies: pulse therapy with CPP and the “gold standard” therapy vs autologous stem cell transplantation after obliterating the native bone marrow with megadoses of CPP.
Conclusion The strategy may improve scleroderma management.