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astemizole

   Also found in: Wikipedia 0.01 sec.
astemizole (stem´izōl),
n brand name: Hismanal;
drug class: antihistamine, H1-histamine antagonist;
action: decreases allergic response by blocking pharmacologic effects of histamine;
uses: rhinitis, allergy symptoms.

astemizole
a long-acting, non-sedating H1-blocking antihistamine used in the treatment of pruritus in dogs and cats.

astemizole
Histamal® Therapeutics A non-sedating H1-receptor antagonist-antihistamine used for seasonal rhinitis–hay fever, hives Adverse effects Minimal sedation, anticholinergic effects


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Astemizole reduced the number of parasites by 80 percent in mice infected with a strain sensitive to chloroquine, one of the primary antimalaria drugs, and by 44 percent in mice with chloroquine-resistant parasites, the researchers report in the August Nature Chemical Biology.
Patients were given 5, 10, or 20 mg/day of astemizole for 13 weeks.
More than 100 million prescriptions were written for terfenadine and astemizole before they were withdrawn from the market because of torsades and sudden death.
 
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