asparagine ligase

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as·par·a·gine li·gase

an acid:ammonia ligase (amide synthetase) forming l-asparagine and l-glutamate from l-aspartate and l-glutamine, with the concomitant cleavage of ATP to AMP and pyrophosphate. Under nonphysiological conditions, the mammalian enzyme can use ammonia as the nitrogen donor. Asparagine ligase also displays a glutaminase-like activity.
References in periodicals archive ?
The team identified the gene affected by the mutation code for asparagine synthetase, the enzyme responsible for synthesising the amino acid asparagine.
In healthy subjects, it seems that the level of asparagine synthetase in the brain is sufficient to supply neurons," Michaud said.
Washington, Dec 2 ( ANI ): The deficiency of asparagine synthetase, which is found in meat, eggs and dairy products, caused by rare genetic disorder affects development of the brain.
His current studies are aimed at understanding the relation between structure and function of ATP synthase and asparagine synthetase with the goal of finding new targets for synthesis of mechanism- based inhibitors of disease related enzymes.
An example of the type of information the researchers are trawling for is provided by a drug called L-asparaginase and a gene called asparagine synthetase (AS).
We've identified a candidate biomarker, asparagine synthetase (ASNS) that may predict L-ASP activity against solid tumors.
ISLAMABAD -- The deficiency of asparagine synthetase, which is found in meat, eggs and dairy products, caused by rare genetic disorder affects development of the brain.
This study evaluated the utility of Oncaspar in solid tumors and lymphomas as well as assessed the correlation of Oncaspar activity with cellular levels of asparagine synthetase (ASNS).
Certain malignant cells, including many pancreatic and ovarian cell lines, lack asparagine synthetase and therefore may depend on exogenous L-asparagine to survive.
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