during pregnancy and congenital malformations.
We have modeled an influenza strain with an infectivity representative of the 1957-58 Asian influenza pandemic and a social contact network reflective of a stylized US town.
For an infectivity similar to that of the 1957-58 Asian influenza pandemic, targeting children and teenagers, by not only closing schools but also by keeping these age classes at home, was effective.
Hong-Kong Influenza: the epidemiologic features of a high school family study analyzed and compared with a similar study during the 1957 Asian influenza epidemic.
With the arrival of Asian influenza in 1957, the sheer number of cases associated with pandemicity again brought the phenomenon of primary influenza virus pneumonia to the attention of physicians in teaching hospitals.
As summarized by Meiklejohn (12) at an international conference on Asian influenza held 3 years after the 1957 onslaught of H2N2, more vaccine was required to initiate a primary antibody response than with the earlier H1 vaccines (almost always observed in heterovariant primed subjects).
In the Asian influenza
pandemic of 1957, in which H2N2 viruses appeared, influenza-associated excess deaths were estimated at >2 million worldwide (3).