Subsequent cell experiments revealed that due to the deletion, the serried gene -- ASGR1 -- is unable to establish the normal structure and function of the protein called the asialoglycoprotein
Autoantibodies detected in CLDs target a wide repertoire of host antigens, which include proteins from the nucleus, the cytoskeleton, liver kidney microsomes, the mitochondria, and the cytoplasm of neutrophilic granulocytes, as well as liver soluble antigens, asialoglycoprotein
receptors, TAA, and stress proteins .
Both Ebola and Marburg viruses use multiple entry mechanisms via receptors such as: hepatocyte receptor asialoglycoprotein
, folate receptor [alpha], dendritic-cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), DC-SIGN-related factors, [beta]1 integrin receptors and human macrophage galactose- and N-acetylgalactosamine-specific C type lectin.
This study evaluated the usefulness of asialoglycoprotein
receptor scintigraphy with [sup.
Topology of asialoglycoprotein
receptor in rat liver subcellular fractions: a ferritin immunoelectron microscopic study.
03 mg/kg of recombinant ApoE was able to fully restore the activity of an siRNA formulated in an iLNP; and,aA alternatively, in the same ApoE knockout model, silencing activity was found to be restored by the use of an exogenous GalNAc ligand that targets the iLNP to the asialoglycoprotein
receptor (ASGR) expressed on hepatocytes, with as little as 0.
The galactose group is recognizable to the hepatic asialoglycoprotein
receptor facilitates hemolysis in patients with alcoholic liver cirrhosis.
On the sinusoidal surface of the hepatocytes, asialoglycoprotein
receptors are expressed abundantly which removes the asialo (galactose-terminal) glycoproteins from the sinusoidal circulation by internalizing the bound protein via endocytosis.
Using the hepatocyte-specific asialoglycoprotein
receptor and the substance that specifically binds to it (i.
12] analogs and transporting them to the liver via an asialoglycoprotein
receptor for secretion into bile.
Earlier research hinted that another cell-surface molecule, the asialoglycoprotein
receptor, is an entry point for Marburg virus.