Ashkenazi Jews

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Ashkenazi Jews

In the 11th century, Ashkenazi Jews comprised 3% of the world's Jewish population, peaking at 92% in 1931; following the holocaust in World War II, that number decreased. Ashkenazi Jews now comprise ±80% of Jews worldwide.

Carrier rates, genetic diseases affecting Ashkenazi Jews
• Factor XI deficiency—1:9 to 1:20
• Gaucher disease, type 1—1:10 to 1:14
• Non-syndrome hearing loss—1:20 to 1:25
• Tay-Sachs disease—1:25 to 1:27
• Cystic fibrosis—1:29
• Familial dysautonomia—1:30
• Glycogen storage disease type III—1:35 (north African Jews)
• Canavan disease—1:40
• BRCA1, BRCA2—1:40
• Fanconi anaemia, type C—1:89
• Niemann-Pick disease, type A—1:90
• Mucolipidosis IV—1:99
• Bloom syndrome—1:110
• Maple syrup urine disease—1:113
• Glycogen storage disease type 1a—1:130
• Abetalipoproteinemia—1:131
• Primary torsion dystonia—1:1000 to 1:3000