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arylsulfatase |
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arylsulfatase a group of enzymes active in the hydrolysis of sulfates and the metabolism of mucopolysaccharides; found in liver, pancreas, kidneys and immature monocytes. Several species of molluscs and Aerobacter spp. serve as commercial sources of the enzyme which is used in analytic endocrinology. arylsulfatase A deficiency see metachromatic leukodystrophy. arylsulfatase B deficiency is the cause of mucopolysaccharidosis VI which occurs in humans and cats. Called also Maroteaux-Lamy syndrome. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| Naglazyme is a normal variant form of arylsulfatase B IUPAC name N-acetylgalactosamin 4-sulfatase) that is lacking in mucopolysaccharidosis VI patients. has announced that the Committee for Orphan Medical Products of the European Agency for the Evaluation of Medicinal Products (COMP/EMEA) has rendered a positive opinion on the company's application for orphan drug designation in the European Community for rhASB (recombinant human arylsulfatase B), as enzyme replacement therapy for patients with Mucopolysaccharidosis (MPS) VI. Nasdaq:BMRN)(Swiss SWX New Market:BMRN), today announced findings from the 24-week, open-label extension portion of the Phase 1 clinical trial of Aryplase(TM) (recombinant human arylsulfatase B), an investigational enzyme replacement therapy for mucopolysaccharidosis VI (MPS VI). |
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