artemisinin

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ar·te·mis·i·nin

(ar'te-mis'in-in),
A sesquiterpene antimalarial and antischistosomal drug derived from Artemisia annua; a. is a potent and rapidly acting blood schizontocide used in the treatment of malaria; active against chloroquine-resistant Plasmodium falciparum and chloroquine-sensitive P. falciparum and P. vivax.

artemisinin

(är′tə-mĭs′ĭ-nĭn)
n.
1. A compound, C15H22O5, that is obtained from a species of artemisia (Artemisia annua) and has antimalarial activity.
2. Any of several semisynthetic derivatives of this compound that are used to treat malaria, usually in combination with other drugs.

artemisinin

An antimalarial drug derived from Artemisia annua . The drug is claimed to be effective in treating cerebral malaria and is active against chloroquine-resistant P. falciparum and chloroquine-sensitive P. falciparum and P. vivax . The drug is a traditional Chinese remedy. See also QUINGHAO.
References in periodicals archive ?
Pre-therapeutic determination of iron-related genes may indicate tumor sensitivity to artemisinins.
The nonsense falcipain 2a mutation, which is present in F32-ART3, might contribute to reducing sensitivity of F32-ART5 to artemisinins and some quinolines (other than chloroquine), but it is unlikely for pyrimethamine, whose activity is not related to hemoglobin metabolism.
A number of molecular studies have been carried out in different countries for detection of point mutation in PfATPase6 gene that was believed to be the main target of artemisinins.
A synthetic version of the world's most effective antimalarial drug, artemisinin, can now be made in just 3 weeks rather than 18 months.
Currently, the most widely used medical treatment for malaria comes from the plant-based compound artemisinin, which has been successful in decreasing malaria infections worldwide -- the World Health Organization (WHO) (http://www.
Artemisinins have been reported to be relatively safe, however there are concerns on some recently reported adverse effects.
Clinical trials conducted by TDR (Training and research in tropical Diseases, Geneva), as early as 2003 have proved the efficacy and superiority of Artemisinin combination therapy (ACT) for chloroquine resistant malaria [7].
in order to allow for early detection of artemisinin resistance.
In this way, the profiles of methylene blue and artemisinins, which quickly and effectively eliminate the parasites in the red blood cells, complement each other," says Professor Dr.
Unlike the case for chloroquine and most other antimalarials, "there's probably no resistance to the artemisinins in Africa," Rosenthal says.
Some international health agencies, pressured by well-meaning activists, are pushing Mozambique to change its entire malaria infrastructure and buy artemisinins now--but won't provide the money to make the drugs affordable, he says.
Prior to the introduction of artemisinin combination therapy (ACT), inappropriate drug use in developing countries had led to the emergence of drug- resistant parasites.