(also known as qinghao su) and its derivatives are a new class of antimalarials derived from the sweet wormwood plant Artemisia annua.
Despite clinical activity of artemisinins
against cancer, longitudinal studies on the efficacy of artemisinin
and Artemisia annua preparations upon longer application times are missing.
The nonsense falcipain 2a mutation, which is present in F32-ART3, might contribute to reducing sensitivity of F32-ART5 to artemisinins
and some quinolines (other than chloroquine), but it is unlikely for pyrimethamine, whose activity is not related to hemoglobin metabolism.
A number of molecular studies have been carried out in different countries for detection of point mutation in PfATPase6 gene that was believed to be the main target of artemisinins
Major finding: Parasite clearance half-life was markedly slow (5 hours or longer), indicating resistance to artemisinins
, across sites in Southeast Asia, but not in India or Africa.
A synthetic version of the world's most effective antimalarial drug, artemisinin
, can now be made in just 3 weeks rather than 18 months.
There is an urgent need for coordinated action against this public health threat, as called for in the Global Plan for Artemisinin
Currently, the most widely used medical treatment for malaria comes from the plant-based compound artemisinin
, which has been successful in decreasing malaria infections worldwide -- the World Health Organization (WHO) (http://www.
have been reported to be relatively safe, however there are concerns on some recently reported adverse effects.
Clinical trials conducted by TDR (Training and research in tropical Diseases, Geneva), as early as 2003 have proved the efficacy and superiority of Artemisinin
combination therapy (ACT) for chloroquine resistant malaria .
in order to allow for early detection of artemisinin
are a class of compounds that include artesunate, artemether, and artemisinin
and have potent antimalarial activity.