Pre-therapeutic determination of iron-related genes may indicate tumor sensitivity to artemisinins
The nonsense falcipain 2a mutation, which is present in F32-ART3, might contribute to reducing sensitivity of F32-ART5 to artemisinins
and some quinolines (other than chloroquine), but it is unlikely for pyrimethamine, whose activity is not related to hemoglobin metabolism.
A number of molecular studies have been carried out in different countries for detection of point mutation in PfATPase6 gene that was believed to be the main target of artemisinins
A synthetic version of the world's most effective antimalarial drug, artemisinin
, can now be made in just 3 weeks rather than 18 months.
Currently, the most widely used medical treatment for malaria comes from the plant-based compound artemisinin
, which has been successful in decreasing malaria infections worldwide -- the World Health Organization (WHO) (http://www.
have been reported to be relatively safe, however there are concerns on some recently reported adverse effects.
Clinical trials conducted by TDR (Training and research in tropical Diseases, Geneva), as early as 2003 have proved the efficacy and superiority of Artemisinin
combination therapy (ACT) for chloroquine resistant malaria .
in order to allow for early detection of artemisinin
In this way, the profiles of methylene blue and artemisinins
, which quickly and effectively eliminate the parasites in the red blood cells, complement each other," says Professor Dr.
Unlike the case for chloroquine and most other antimalarials, "there's probably no resistance to the artemisinins
in Africa," Rosenthal says.
Some international health agencies, pressured by well-meaning activists, are pushing Mozambique to change its entire malaria infrastructure and buy artemisinins
now--but won't provide the money to make the drugs affordable, he says.
Prior to the introduction of artemisinin
combination therapy (ACT), inappropriate drug use in developing countries had led to the emergence of drug- resistant parasites.