arsenical

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arsenical

 [ahr-sen´ĭ-k'l]
1. pertaining to arsenic.
2. a compound containing arsenic; arsenicals were once widely used in medicine, but have now mostly been replaced by antibiotics. However, some are still used to treat infectious diseases, especially those caused by protozoa, as well as skin disorders and blood dyscrasias; they must be administered with caution because of their toxicity. All arsenicals are toxic to humans and some are carcinogenic. See also arsenic poisoning.

ar·sen·i·cal

(ar-sen'i-kăl),
1. A drug or agent, the effect of which depends on its arsenic content.
2. Denoting or containing arsenic.

arsenical

(är-sĕn′ĭ-kəl)
adj.
Of or containing arsenic.
n.
A drug or preparation containing arsenic.

ar·sen·i·cal

(ahr-sen'i-kăl)
1. Denoting or containing arsenic.
2. A drug or agent, the effect of which depends on its arsenic content.
3. A class of chemical agents that contain arsenic.

arsenical

1. pertaining to arsenic.
2. a compound containing arsenic.

arsenical herbicide
includes monosodium or disodium methanearsonates. See also organic arsenical (below).
organic arsenical
includes aliphatic organic arsenicals, e.g. the pharmaceuticals cacodylic and phenarsonic acids, the herbicides monosodium and disodium methanearsonates, aromatic organic arsenicals, e.g. trivalent phenylorganic arsenicals like thiacetarsamide, arsphencomplexamine, and pentavalent phenylorganic arsenicals like arsanilic acid, roxarsone, nitarsone. Poisoning by organic arsenicals causes blindness and incoordination or restlessness, convulsions, incoordination, screaming. Recovery is spontaneous if the toxin is discontinued but some piglets may remain blind.
arsenical pyrites
an arsenic-rich ore.
arsenical sheepdip, cattledip
usually contains arsenic and sulfur with 20% soluble arsenic and 3% insoluble arsenious sulfide.
arsenical smoke
factory smoke effluent from processes using arsenic-rich ores may pollute local pasture with arsenic trioxide.
arsenical weedkiller
contains sodium or potassium arsenite or thioarsenites. They may contain up to 40% arsenic trioxide.
References in periodicals archive ?
Comparative inhibition of yeast glutathione reductase by arsenicals and arsenothiols.
To determine the efficiency of iAs metabolism, the proportion of total urinary As comprising the individual arsenicals iAs, MMAs, and DMAs (e.
In this way, only those arsenicals giving volatile arsines were detected.
Because cells provide a reducing environment, the toxic trivalent arsenicals are relatively stable even in samples stored for weeks (Currier et al.
Comparative in vitro methylation of trivalent and pentavalent arsenicals.
A just published preclinical article, "Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line", by Boise et al in Molecular Cancer Therapeutics May 2009, further elucidates the mechanism of action of darinaparsin and highlights substantial differences between darinaparsin and inorganic arsenic trioxide, aspects of darinaparsin likely to be included in the discussion session following the abstract presentation, "Mechanisms of Action of Arsenicals in Hematologic Malignancies".
As with ZIO-101/102 and the other licensed organic arsenicals, ZIO-201 and the IPM analogs are a product family offering multiple registration paths and commercialization alternatives-what we like to call multiple and timely shots on goal.
DMA, MMA, As(V), and unidentified arsenicals have also been found in marine animals.
Patent and Trademark Office for patent applications numbered 11/252,966 and 11/349,043, covering claims for various organic arsenic compounds, including purified crystalline darinaparsin (ZIO-101), glycolic arsenicals, and the oral pharmaceutical composition of an organic arsenic compound, and their use in the treatment of cancer.
Preabsorptive metabolism of sodium arsenate by anaerobic microbiota of mouse cecum forms a variety of methylated and thiolated arsenicals.
The emerging activity profile of ZIO-102 coupled with its lipid solubility may extend the applicability of these organic arsenicals into new areas of clinical utility," commented Jonathan J.