Arimidex


Also found in: Dictionary.
Related to Arimidex: tamoxifen

anastrozole

Arimidex

Pharmacologic class: Nonsteroidal aromatase inhibitor

Therapeutic class: Antineoplastic

Pregnancy risk category D

Action

Reduces serum estradiol levels with no significant effect on adrenocorticoid or aldosterone level; decreases stimulating effect of estrogen on tumor growth

Availability

Tablets: 1 mg

Indications and dosages

Postmenopausal women with hormone receptor-unknown or hormone receptor-positive advanced breast cancer or with advanced breast cancer after tamoxifen therapy; adjuvant treatment for hormone receptor-positive breast cancer

Adults: 1 mg P.O. daily

Contraindications

• Hypersensitivity to drug or its components
• Women of childbearing age

Precautions

Use cautiously in:
• ischemic heart disease
• breastfeeding patients
• children (safety and efficacy not established).

Administration

• Verify that patient isn't pregnant before giving drug.

Adverse reactions

CNS: headache, weakness, dizziness, depression, paresthesia, lethargy

CV: chest pain, peripheral edema, vasodilation, hypertension, thromboembolic disease

EENT: pharyngitis

GI: nausea, vomiting, diarrhea, constipation, abdominal pain, anorexia, dry mouth

GU: vaginal bleeding, leukorrhea, vaginal dryness, pelvic pain

Musculoskeletal: decreased bone mineral density, fractures, bone or back pain, muscle weakness

Respiratory: dyspnea, cough

Skin: rash

Other: food distaste, weight gain, swelling, hot flashes, flulike symptoms, tumor flare hypersensitivity reactions (including anaphylaxis, angioedema, urticaria)

Interactions

Drug-diagnostic tests.Hepatic enzymes, low-density lipoproteins, total cholesterol: increased levels

Patient monitoring

Monitor patient closely for hypersensitivity reactions.
• Check regularly for signs and symptoms of thromboembolic disease, especially dyspnea and chest pain.
• Monitor for circulatory overload (suggested by peripheral edema, cough, and dyspnea).
• Assess for signs and symptoms of depression. Evaluate patient for suicidal ideation.
• Monitor liver function test results.

Patient teaching

Instruct patient to immediately notify prescriber if signs and symptoms of hypersensitivity occur (such as itching or swelling of face, lips, or throat).

Advise patient to immediately report signs and symptoms of thromboembolic disease and circulatory overload.
• Emphasize importance of preventing pregnancy during therapy.
• Tell patient to contact prescriber if she develops signs or symptoms of depression.
• Caution patient to avoid driving and other hazardous activities until she knows how drug affects concentration and alertness.
• Advise patient to minimize GI upset by eating small, frequent servings of food and drinking plenty of fluids.
• Inform patient that she'll undergo regular blood testing during therapy.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the tests mentioned above.

Arimidex

a trademark for an aromatase inhibitor (anastrozole) used for treating estrogen-receptor-positive breast cancer, primarily in postmenopausal women.

anastrozole

An aromatase inhibitor, which converts androstenedione to estradiol in peripheral fat.
 
Indications
Postmenopausal women with advanced oestrogen-dependent breast cancer that does not respond to tamoxifen; unlike tamoxifen, anastrozole is not associated with increased risk of endometrial cancer.

Arimidex®

Anastrozole Oncology A nonsteroidal 3rd-generation selective aromatase inhibitor used to manage postmenopausal ♀ whose advanced breast CA is resistant to tamoxifen. See Breast cancer.

Arimidex

A brand name for ANASTROZOLE.
References in periodicals archive ?
AstraZeneca plans to continue to market and supply ATACAND, ATACAND HCT, ARIMIDEX and CASODEX outside of the US.
ANI Pharmaceuticals Inc (Nasdaq: ANIP), an integrated specialty pharmaceutical company developing, manufacturing, and marketing branded and generic prescription pharmaceuticals, has acquired the NDAs and United States rights to market ATACAND, ATACAND HCT, ARIMIDEX, and CASODEX from AstraZeneca, an Anglo-Swedish multinational pharmaceutical and biopharmaceutical company.
Data Source: 10-year follow-up data from the Arimidex, Tamoxifen Alone or in Combination (ATAC) trial.
Mrs Langdon, a carer, is now taking a daily dose of the breast cancer drug Arimidex.
from Parma, Ohio: Arimidex is used to decrease the risk of recurrence of breast cancer that is hormone receptor positive.
In the longest study of post-menopausal women taking both anastrozole - also known as Arimidex - and tamoxifen, those on the former were more likely to remain cancer free.
The Government's drugs watchdog has approved the use of Arimidex, Femara and Aromasin alongside "gold standard" drug Tamoxifen.
Scotland became the first part of the UK this week to approve Arimidex for post-menopausal women with early breast cancer.
Preliminary results of laboratory analyses for products from these companies intercepted on their way to the United States have identified counterfeit versions of the following prescription drugs: the cholesterol-lowering agents Lipitor (atorvastatin), Crestor (rosuvastatin), and Zetia (ezetimibe); the antihypertensives Diovan (valsartan) and Hyzaar (losartan-hydrochlorothiazide); Actonel (risedronate), a bisphosphonate for osteoporosis; Nexium (esomeprazole) for gastroesophageal reflux disease; Celebrex (celecoxib) for arthritis-related pain; Arimidex (anastrozole) for breast cancer; and Propecia (finasteride), for male pattern baldness.
Preliminary results of laboratory analyses for products from these companies intercepted on their way to the United States have identified counterfeit versions of the fbllowing prescription drugs: the cholesterol-lowering agents Lipitor (atorvastatin), Crestor (rosuvastatin), and Zetia (ezetimibe); the antihypertensives Diovan (valsartan) and Hyzaar (losartan-hydrochlorothiazide); Actonel (risedronate), a bisphosphonate for osteoporosis; Nexium (esomeprazole) for gastroesophageal reflux disease; Celebrex (celecoxib) for arthritis-related pain; Arimidex (anastrozole) for breast cancer; and Propecia (finasteride), for male pattern baldness.
They are Arimidex (anastro-zole), Femara (letrozole) and Aromasin (exemestane) and will be available on the NHS alongside the "gold standard" drug tamoxifen.
They are Arimidex, Femara and Aromasin and will be available on the NHS alongside the "gold standard" drug tamoxifen.