ALOX5

(redirected from Arachidonate 5-lipoxygenase)
Also found in: Wikipedia.

ALOX5

A gene on chromosome 10q11.2 that encodes a member of the lipoxygenase (LOX) family of non-heme iron dioxygenases, which are involved in the production and metabolism of fatty acid hydroperoxidases.

Molecular pathology
Mutations in the ALOX5 promoter region lead to a reduced response to antileukotriene drugs used for asthma, and may also be linked to atherosclerosis and several cancers.
Mentioned in ?
References in periodicals archive ?
Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells.
Ingolfsdottir K, Gissurarson SR, Muller-Jakic B, Breu W, Wagner H (1996) Inhibitory effects of the lichen metabolite lobaric acid on arachidonate 5-lipoxygenase in vitro.
Medisyn's approach will involve identification of inhibitors for both cyclooxygenase-2 (COX-2) and arachidonate 5-lipoxygenase (5-LO), two potent mediators of inflammation.
Rapid induction of apoptosis in prostate cancer cells by selenium: reversal by metabolites of arachidonate 5-lipoxygenase.