Pathophysiology of ascites and dilutional hyponatremia: Contemporary use of aquaretic
AVP receptor antagonists as novel aquaretic agents also deserve study as adjunctive therapy for EAH given their recent approval for similar clinical conditions.
Arginine vasopressin V2 receptor antagonists deserve study as adjunctive therapy, as these pure aquaretic agents rapidly normalize serum [Na+] safely in similar clinical conditions (9).
Conventional diuretic drugs, which are currently used to treat ascites, have the drawback that they promote the excretion of both salt and water, whereas M0002, because it is an electrolyte-sparing aquaretic
causes much lower levels of salt excretion.
Used as a diuretic, the herb is actually an aquaretic
that facilitates the excretion of water only, not sodium and water.
The most common adverse events (10% and nominally significantly more than placebo) associated with tolvaptan treatment were related to its aquaretic
mode of action: thirst (55.
Newer pharmacologic agents of interest that have been studied in euvolemic and hypervolemic hyponatremia are vasopressin-2 receptor blockers, referred to as aquaretics
Unlike diuretics, aquaretics
do not eliminate sodium and, therefore, are not as likely to create a dangerous sodium-water imbalance in the body.