aquaretics

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aquaretics

drugs that bind to vasopressin receptors in the renal collecting duct promoting excretion of solute-free water.
References in periodicals archive ?
AVP receptor antagonists as novel aquaretic agents also deserve study as adjunctive therapy for EAH given their recent approval for similar clinical conditions.
Arginine vasopressin V2 receptor antagonists deserve study as adjunctive therapy, as these pure aquaretic agents rapidly normalize serum [Na+] safely in similar clinical conditions (9).
Conventional diuretic drugs, which are currently used to treat ascites, have the drawback that they promote the excretion of both salt and water, whereas M0002, because it is an electrolyte-sparing aquaretic causes much lower levels of salt excretion.
Used as a diuretic, the herb is actually an aquaretic that facilitates the excretion of water only, not sodium and water.
The most common adverse events (10% and nominally significantly more than placebo) associated with tolvaptan treatment were related to its aquaretic mode of action: thirst (55.
Satavaptan (SR121463), a vasopressin V2 receptor antagonist, confirms in study DFI4522 that a pure aquaretic agent has therapeutic interest in the reduction in the number of paracentesis in recurrent ascites.
Conivaptan has a unique aquaretic effect, resulting in increased excretion of free water by increasing urine output without increasing the sodium output.
The company's second product ZP120, a novel aquaretic, has completed a successful Phase I trial for acute heart failure.
M0002 is an orally-active selective vasopressin 2 receptor antagonist and a member of a new class of compounds, known as aquaretics, which inhibit water reabsorption from the renal collecting duct.
M0002 is a selective vasopressin 2 receptor antagonist and is a member of a new class of compounds - aquaretics - that produce significant diuresis without the loss of electrolytes.