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apolipoprotein E |
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apolipoprotein E, a protein component of lipoprotein complexes found in very-low-density lipoprotein (VLDL), high-density lipoprotein, chylomicrons, and chylomicron remnants. It facilitates hepatic uptake of chylomicron and VLDL remnants and is elevated in patients with type III hyperlipoproteinemia. One form of apolipoprotein E has been linked to Alzheimer's disease. apolipoprotein E A 34-kD cholesterol-binding glycoprotein, which comprises 15% of VLDL; apoE maps to chromosome 19, is secreted by macrophages that mediate the uptake of lipoproteins–VLDL, HDL, LDL and cholesterol esters into cells via
distinct binding domains for each receptor; apo-E has a central role in the metabolism of TG-rich lipoproteins, and mediates the uptake of chylomicrons and VLDL by the liver How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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The 121 individuals possessing at least one copy of a specific variant of the apolipoprotein E gene, which influences brain-cell repair, performed as well as the rest at age 11. Recent excitement has centered around the discovery of the relationship between the apolipoprotein E (apoE) gene and AD. Apolipoprotein E exists in three forms -- apoE2, E3, E4 -- and plays a fundamental role in regulating lipid homeostasis and maintaining neuronal integrity and function. |
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