apolipoprotein B


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ap·o·lip·o·pro·tein B

[MIM*107730]
an apolipoprotein found in chylomicrons, LDL, VLDL, and IDL. Elevated in the plasma of patients with familial hyperlipoproteinemia; it exists in two forms, B-100 and B-48.

APOB

A gene on chromosome 2p24-p23 that encodes apolipoprotein B, the main apoliprotein of chylomicrons and low-density lipoproteins, which appears in plasma as two main isoforms: apoB48 (which is synthesised exclusively in the gut) and apoB100 (which is synthesised in the liver).

Molecular pathology
APOB mutations cause hypobetalipoproteinaemia, normotriglyceridemic hypobetalipoproteinaemia, and hypercholesterolaemia due to ligand-defective apoB.
References in periodicals archive ?
Variation of apolipoprotein B gene is associated with myocardial infarction and lipoprotein levels in Danes.
Table 20: World Long-term Projections for Apolipoprotein B Tests by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in Million Units for Years 2011 through 2015 (includes corresponding Graph/Chart) II-59
Kanda apolipoprotein B duzeyinin, daha once bircok baska populasyonda gosterildigi gibi, halkimizda da gelecekteki koroner kalp hastaligini dusuk yogunluklu lipoprotein (LDL) -kolesterol duzeyinden daha iyi ongordurdu gune iliskin calismamiza karsi, biyokimya acisindan bazi elestiriler getiren "editore mektup" dikkat cekici.
Regression of coronary artery disease as a result o intensive lipid-lowering therapy in men with high levels of apolipoprotein B.
Market Analytics III-13 Table 47: US Recent Past, Current & Future Analysis for Cholesterol Testing by Test Type - Lipid Panel Test/Complete Lipid Profile, Apolipoprotein B, and Other Cholesterol Tests Independently Analyzed with Annual Tests in Thousands for Years 2013 through 2020 (includes corresponding Graph/Chart) III-13
Conclusions: Apolipoprotein B, which marks small, dense LDL particles in plasma is a better predictor of incident CHD than LDL-cholesterol among Turkish adults.
The other apolipoproteins were discovered by separation of the proteins after delipidation of plasma lipoproteins--initially classified as apolipoprotein A if present in [alpha]-lipoproteins (HDL), apolipoprotein B if in [beta]-lipoproteins (LDL), and apolipoprotein C if in pre-[beta]-lipoprotein (VLDL) (27).
They have also been shown to be effective in lowering cholesterol, triglyceride and apolipoprotein B levels.
para]]NEW YORK, June 10, 2015 /PRNewswire/ -- This report analyzes the worldwide markets for Cholesterol Testing in Million Units by the following Product Segments: Lipid Panel Test/Complete Lipid Profile, Apolipoprotein B, and Other Apolipoprotein Tests.
Secondary measures included VLDL cholesterol, apolipoprotein A-I, and apolipoprotein B.
Plasma low-density-lipoprotein (LDL) cholesterol and apolipoprotein B concentrations increased significantly (0.