apolipoprotein B


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ap·o·lip·o·pro·tein B

[MIM*107730]
an apolipoprotein found in chylomicrons, LDL, VLDL, and IDL. Elevated in the plasma of patients with familial hyperlipoproteinemia; it exists in two forms, B-100 and B-48.

APOB

A gene on chromosome 2p24-p23 that encodes apolipoprotein B, the main apoliprotein of chylomicrons and low-density lipoproteins, which appears in plasma as two main isoforms: apoB48 (which is synthesised exclusively in the gut) and apoB100 (which is synthesised in the liver).

Molecular pathology
APOB mutations cause hypobetalipoproteinaemia, normotriglyceridemic hypobetalipoproteinaemia, and hypercholesterolaemia due to ligand-defective apoB.
References in periodicals archive ?
Finally, apolipoprotein A1, apolipoprotein B, apolipoprotein B/apolipoprotein A1 ratio, and total cholesterol/HDL cholesterol ratio did not change in response to normal food intake compared with fasting concentrations in either the diabetic or nondiabetic individuals (Fig.
Table 20: World Long-term Projections for Apolipoprotein B Tests by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan), Latin America and Rest of World Markets Independently Analyzed with Annual Sales Figures in Million Units for Years 2011 through 2015 (includes corresponding Graph/Chart) II-59
Apolipoprotein B and apolipoprotein A1 as predictors of coronary artery disease.
Kanda apolipoprotein B duzeyinin, daha once bircok baska populasyonda gosterildigi gibi, halkimizda da gelecekteki koroner kalp hastaligini dusuk yogunluklu lipoprotein (LDL) -kolesterol duzeyinden daha iyi ongordurdu gune iliskin calismamiza karsi, biyokimya acisindan bazi elestiriler getiren "editore mektup" dikkat cekici.
Conclusions: Apolipoprotein B, which marks small, dense LDL particles in plasma is a better predictor of incident CHD than LDL-cholesterol among Turkish adults.
Some consideration of methodology and standardization of apolipoprotein B immunoassay.
The other apolipoproteins were discovered by separation of the proteins after delipidation of plasma lipoproteins--initially classified as apolipoprotein A if present in [alpha]-lipoproteins (HDL), apolipoprotein B if in [beta]-lipoproteins (LDL), and apolipoprotein C if in pre-[beta]-lipoprotein (VLDL) (27).
The p27 catalytic subunit of the apolipoprotein B mRNA editing enzyme is a cytidine deaminase.
Hyperlipidemia and coronary heart disease (CHD) are associated with genetic variation in the apolipoprotein B (apoB) gene (1).
Electroimmunoassay, radioimmunoassay, and radial immunodiffusion assay evaluated for quantification of human apolipoprotein B.
1] ([micro]g/L) = 369 X apolipoprotein B (g/L) X apolipoprotein [A.