APOA1

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APOA1

A gene on chromosome 11q23-q24 that encodes apolipoprotein A1, the main protein component of high-density lipoprotein (HDL) in plasma, which promotes cholesterol efflux from tissues to the liver for excretion and is a cofactor for lecithin cholesterolacyltransferase (LCAT), which is responsible for forming most plasma cholesteryl esters.
 
Molecular pathology
APOA1 mutations cause HDL deficiency (e.g., Tangier disease and systemic non-neuropathic amyloidosis).
References in periodicals archive ?
OVA1 measures the levels of five tumor-secreted proteins (Beta-2 microglobulin, CA 125II, apolipoprotein A1, prealbumin and transferrin), while measuring the host response to ovarian cancer.
Apolipoprotein A1 (apoA1) is the primary protein present in HDL, providing the structure of the molecule that allows it to transfer cholesterol out of the artery wall and deliver it to the liver, from which cholesterol is excreted.
Blood samples obtained during physical examinations were analyzed for glucose, fasting insulin, C-reactive protein, fibrinogen, homocysteine, triglycerides, total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1, apolipoprotein B, and 25-hydroxyvitamin D [25(OH)D].
In terms of the primary outcome measures, levels of fasting serum glucose, cholesterol, triglycerides, LDL/HDL cholesterol, apolipoprotein B (ApoB) and apolipoprotein A1 (ApoA1), urinary C-peptide and HOMA indices were all reduced.
The results revealed no association between HDL, apolipoprotein A1 and C3 concentrations and cardiovascular events.
Compared with women who reported no hot flashes, women who reported 1-5 days of hot flashes or 6 or more days of hot flashes during the past 2 weeks were significantly more likely to have elevated levels of LDL cholesterol, triglycerides, apolipoprotein B, and apolipoprotein A1.
They focused on the production of apolipoprotein A1 (ApoA1), a protein that is the major component of "good" cholesterol, and apolipoprotein B (ApoB), the main component of "bad" cholesterol.
In the study, women on either a standard or extended-release contraceptive patch had higher levels of HDL cholesterol and its constituent apolipoprotein A1 (ApoA1), compared with when they were taking oral contraceptives; however, the effects of patch and oral formulations on atherogenic lipoproteins were similar, Dr.
Cardiovascular Risk Markers * Apolipoprotein A1 * Apolipoprotein B * high sensitivity C-reactive protein (hsCRP) * Fibrinogen * White blood cell count * Homocysteine * B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) * Lipoprotein (a) * Lipoprotein subclasses and particle concentration
An improved method for the quantitation of apolipoprotein B and apolipoprotein A1 in dried blood spots.
Colesevelam significantly increased hepatic gene expression for scavenger receptor type BI, apolipoprotein A1, LCAT, cholesterol ester transfer protein, cholesterol 7-[alpha]-hydroxylase (CYP7A1), low-density lipoprotein receptor, and liver X receptor (LXR).
They have inherited a gene that codes for Apolipoprotein A1, a special protein that scavenges cholesterol from the bloodstream.