lithium carbonate

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lithium

 (Li) [lith´e-um]
a chemical element, atomic number 3, atomic weight 6.939. (See Appendix 6.)
lithium carbonate a psychotropic drug used to treat acute manic attacks in bipolar disorder and, when given on a maintenance basis, to prevent the recurrence of manic-depressive episodes. The desired serum levels are in the range 0.5–1.5 mEq/L. Life-threatening central nervous system effects and kidney damage occur at levels above 3.0 mEq/L. It is very important that the levels be carefully controlled. Lithium should not be given to patients with severe renal or cardiovascular disease or taken with diuretics because the potential for toxicity is very high. It is suspected of causing birth defects and should not be used during pregnancy.
lithium citrate the citrate salt of lithium, having the same actions and uses as the carbonate salt.

lith·i·um car·bon·ate

an agent used in the treatment and prophylaxis of depressive, hypomanic, and manic phases of bipolar affective disorders.

lithium carbonate

n.
A white granular powder, Li2CO3, used as a drug primarily to treat bipolar disorder and in the manufacture of glass and ceramics.

lithium carbonate

an antimanic agent.
indication It is prescribed in the treatment of manic episodes of manic-depressive disorder.
contraindications It is used with caution in the presence of renal or cardiovascular disease and is not recommended for children under 12 years of age. Known hypersensitivity to this drug and pregnancy prohibit its use.
adverse effects Among the most serious adverse effects are renal damage, polydipsia and polyuria, and impairment of mental and physical abilities. Retention of sodium and fluid may occur.

lithium carbonate

LiCO3 Pharmacology An alkali used to treat bipolar I disorder, which blocks neurotransmission at the 'second messenger' phosphoinositide-mediated cholinergic neurons in the hippocampus , inhibiting release and uptake of norepinephrine at nerve endings by inhibiting receptor-mediated synthesis of cAMP Neuropharmacologic effects-antimanic Blocks development of dopamine receptor supersensitivity, ↑ GABA function, ↑ acetylcholine function Antidepressant ↑ 5-HT function, ↓ β-adrenoceptor stimulation of adenylate cyclase, ↓ α2-adrenoceptor function Thymoleptic ↓ Neurotransmitter-coupled adenylate cyclase activity and cAMP formation, ↓ receptor-G protein coupling, ↓ phosphoinositide metabolism, alters kinetics of alkali cations–Na+, K+, Ca2+, Mg2+  Side effects Hyperirritability, hyperpyrexia, stupor, coma, gastroenteritis, cardiovascular disease–eg, arrhythmia, hypotension, ↓ ST wave, T inversion, osteoporosis Teratogenesis Cardiac malformations in 10% of infants born to lithium-treated ♀ Toxicity Overdose causes death in14 of Pts Treatment K+-sparing drugs
Lithium toxicity
< 1.5 mmol/L Nausea, tremor, mild polyuria
1.5–2.5 mmol/L Diarrhea, vomiting, polyuria, coarse tremor, muscle fasciculation, ataxia, weakness, sedation
2.5–4.0 mmol/L Muscle hypertonia, choreiform movement, ↑ deep muscle reflexes, seizures, focal neurologic signs, impaired consciousness, confusion, stupor
> 4.0 mmol/L Coma, death

lith·i·um car·bon·ate

(lith'ē-ŭm kahr'bŏ-nāt)
Agent used to treat depressive, hypomanic, and manic phases of bipolar affective disorders.

lithium carbonate

agent used in the prophylaxis and treatment of bipolar disorder and recurrent depression; side-effects include renal impairment, polydipsia and polyuria, weight gain and oedema, drowsiness, ataxia, coarse tremor and reduced coordination; may increase rate of plantar callous formation

lith·i·um car·bon·ate

(lithē-ŭm kahrbŏ-nāt)
Agent used to treat depressive, hypomanic, and manic phases of bipolar affective disorders.

lithium

a chemical element, atomic number 3, atomic weight 6.939, symbol Li. See Table 6.

lithium carbonate
used in the treatment of canine cyclic hematopoiesis to stabilize numbers of neutrophils.