antitoxin

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antitoxin

 [an´tĭ-tok″sin]
a particular kind of antibody produced in the body in response to the presence of a toxin; see also immunity. adj., adj an´titoxic.
botulism antitoxin an equine antitoxin against the toxins produced by the types A and B and/ or E strains of Clostridium botulinum; administered intravenously in the postexposure prophylaxis and treatment of botulism, other than infant botulism. Generally trivalent (ABE) antitoxin is used.
diphtheria antitoxin equine antitoxin from horses immunized against diphtheria toxin or the toxoid; administered intramuscularly or intravenously in the treatment of suspected cases of diphtheria.
equine antitoxin an antitoxin derived from the blood of healthy horses immunized against a specific bacterial toxin.
tetanus antitoxin equine antitoxin from horses that have been immunized against tetanus toxin or toxoid; used for the passive prevention and treatment of tetanus. It is rarely used, tetanus immune globulin being preferred.

an·ti·tox·in

(an'tē-tok'sin),
Antibody formed in response to antigenic poisonous substances of biologic origin, such as bacterial exotoxins (for example, those elaborated by Clostridium tetani or Corynebacterium diphtheriae), phytotoxins, and zootoxins; in general usage, antitoxin refers to whole, or globulin fraction of, serum from people or animals (usually horses) immunized by injections of the specific toxoid. Antitoxin neutralizes the pharmacologic effects of its specific toxin in vitro, and also in vivo if the toxin is not already fixed to the tissue cells.
[anti- + G. toxikon, poison]

antitoxin

/an·ti·tox·in/ (an´te-) (an´ti-tok″sin) antibody produced in response to a toxin of bacterial (usually an exotoxin), animal (zootoxin), or plant (phytotoxin) origin, which neutralizes the effects of the toxin.an´titoxic
botulism antitoxin  an equine antitoxin against toxins of the types A and B and/or E strains of Clostridium botulinum.
diphtheria antitoxin  equine antitoxin from horses immunized against diphtheria toxin or the toxoid.
equine antitoxin  an antitoxin derived from the blood of healthy horses immunized against a specific bacterial toxin.
tetanus antitoxin  equine antitoxin from horses that have been immunized against tetanus toxin or toxoid.

antitoxin

(ăn′tē-tŏk′sĭn, ăn′tī-)
n.
1. An antibody formed in response to and capable of neutralizing a specific toxin of biological origin.
2. An animal or human serum containing antitoxins. It is used in medicine to prevent or treat diseases caused by the action of biological toxins, such as tetanus, botulism, and diphtheria.

antitoxin

[-tok′sin]
Etymology: Gk, anti + toxikon, poison
a subgroup of antisera usually prepared from the serum of horses immunized against a particular toxin-producing organism, such as botulism antitoxin given therapeutically in botulism and tetanus and diphtheria antitoxins given prophylactically to prevent those infections.

antitoxin

Immunology An antibody-rich serum from an animal stimulated with specific antigens or bacterial toxins–eg, botulinus, tetanus or diphtheria, which is used to provide passive immunity. See Passive immunity.

an·ti·tox·in

(an'tē-tok'sin)
Antibody formed in response to antigenic poisonous substances of biologic origin (e.g., bacterial exotoxins, phytotoxins, and zootoxins); in general usage, serum from humans or animals (usually horses) immunized by injections of the specific toxoid. Antitoxin neutralizes the pharmacologic effects of its specific toxin.
[anti- + G. toxikon, poison]

antitoxin

An ANTIBODY formed by the immune system in response to the presence of TOXIN, produced by bacteria.

antitoxin

a type of ANTIBODY that neutralizes TOXINS.

Antitoxin

An antibody that is capable of neutralizing the specific toxin (a specific cause of disease) that stimulated its production in the body and is produced in animals for medical purposes by injection of a toxin or toxoid with the resulting serum being used to counteract the toxin in other individuals.

antitoxin,

n a substance used to counter directly the effects of a toxin. May be produced by the body or administered from outside the body.

an·ti·tox·in

(an'tē-tok'sin)
Antibody formed in response to antigenic poisonous substances of biologic origin; in general usage, antitoxin refers to whole, or globulin fraction of, serum from people immunized by injections of the specific toxoid.
[anti- + G. toxikon, poison]

antitoxin (an´tētok´sin),

n a subgroup of antisera usually prepared from the serum of horses immunized against a particular toxin-producing organism, such as botulism antitoxin and diphtheria antitoxin given prophylactically to prevent those infections.

antitoxin

a particular kind of antibody produced in the body in response to the presence of a toxin or toxoid. Most commonly used in the treatment of diseases caused by clostridial toxins, e.g. botulinum and tetanus. See also immunity.

gas gangrene antitoxin
serum containing antitoxic antibodies; prepared from the blood of healthy animals immunized against gas-producing organisms of the genus Clostridium.
tetanus antitoxin
preparation from the blood serum or plasma of healthy animals immunized against tetanus toxin. Used for prophylaxis after injury because of its immediate effect. Active immunization is preferred for long-term protection, particularly for many clostridial diseases such as tetanus.
References in periodicals archive ?
The contract for the new antitoxin was issued to Elusys Therapeutics Inc.
In the present study, toxin antitoxin neutralization test on the skin of albino guinea pigs and lethal toxicity test I/P in mice were applied using specific antitoxin to detect and identify the toxigenic strains of C.
Contributions to the knowledge of the toxin and antitoxin of Bacilius botulinus.
The Centers for Disease Control and Prevention (CDC; Atlanta, GA, USA) provided heptavalent (anti-ABCDEFG) equine F(ab')2 antitoxin, but because of progressive clinical improvement, it was surmised that no toxin remained in circulation, and the antitoxin was not administered.
The current research areas of interest include vaccines, antitoxins, therapeutics, antimicrobial drugs, radiological/nuclear threat countermeasures, chemical threat countermeasures, and clinical diagnostic tools.
Exposure to botulinum toxins can lead to death due to respiratory failure unless ventilation is assisted mechanically; therefore, rapid diagnosis and access to intensive medical care and antitoxin are vitally important.
BSV's product portfolio is comprised of a wide range of products covering biologicals, monoclonal antibodies, equine antitoxins and serums, hormones, anesthetics, antifungals, and cardiovascular formulations.
Toxin-binding antibodies have been known to be potent antitoxins since the landmark studies of Behring and Kitasato, which showed that immune sera protected against diphtheria (68).
Government and their acute recognition of the need for advanced technology for detection, diagnostics, communications, post-exposure prophylaxis, vaccines, treatment; including better antibiotics, monoclonal antibodies and antitoxins as well as new methods of decontamination," said David Wright.
New antibiotics, antivirals, and antitoxins are also being developed, many in the private sector by companies, such as NovaCal, SIGA, and Xenerex that expect to market those new drugs for biodefense and for other applications.
The death toll would be high (as much as 50,000 he estimated), due to the current insufficient supply of ventilators and antitoxins in the U.
When such antitoxins become available, we will be able to deliver the one-two punch that knocks out anthrax infection even at the dangerous, symptomatic stage: antibiotics to destroy the bacteria and antitoxins to remove the toxin.