antithrombin (redirected from Antithrombin deficiency, congenital)

antithrombin /an·ti·throm·bin/ (-throm´bin) any naturally occurring or therapeutically administered substance that neutralizes the action of thrombin and thus limits or restricts blood coagulation.

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antithrombin I  fibrin, referring to its capacity to adsorb thrombin and thus neutralize it.

antithrombin III  a plasma α of the serpin family that inactivates thrombin and also inhibits certain coagulation factors and kallikrein. Inherited deficiency is associated with recurrent deep vein thrombosis and pulmonary emboli; the complications are prevented and treated with a preparation of antithrombin III from pooled human plasma.

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an·ti·throm·bin (nt-thrmbn, nt-)

n.

An anticoagulant that inhibits or prevents the effects of thrombin.

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Antithrombin

Any substance that counters the effect of thrombin, an enzyme that converts fibrinogen into fibrin, leading to blood coagulation.

Mentioned in: Hypercoagulation Disorders

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antithrombin

[-throm′bin]

a substance that inhibits the action of thrombin.

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antithrombin [an″te-throm´bin]

any naturally occurring or therapeutically administered substance that neutralizes the action of thrombin and thus limits or restricts blood coagulation.

antithrombin I fibrin, referring to the capacity of fibrin to adsorb thrombin and thus neutralize it.

antithrombin III a naturally occurring inhibitor of blood coagulation; it is an α₂-globulin member of the serpin group, synthesized in the liver and found in the plasma and various extravascular sites. It inactivates thrombin as well as certain coagulation factors and kallikrein. Inherited deficiency of the protein, an autosomal dominant disorder, is associated with recurrent deep vein thrombosis and pulmonary emboli. Complications from the disorder are prevented and, in conjunction with heparin, treated with a preparation of antithrombin III from pooled human plasma, administered intravenously.

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antithrombin

any naturally occurring or therapeutically administered substance that neutralizes the action of thrombin and thus limits or restricts blood coagulation.

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antithrombin III (AT III)

an alpha₂-globulin synthesized in the liver which is a natural inhibitor of clotting.