antithrombin III deficiency

(redirected from Antithrombin deficiency)

antithrombin III deficiency

Congenital antithrombin III deficiency An AD condition characterized by ↑ risk of DVT and PE. See Antithrombin III.

antithrombin III deficiency

An inherited deficiency of certain protein-splitting enzymes (proteases) which normally participate in the blood clotting cascade sequence. Women with this deficiency are at serious risk of developing THROMBOEMBOLISM in pregnancy and HEPARIN treatment is necessary.
References in periodicals archive ?
These protein deficiencies/abnormalities are genetic and include entities such as antithrombin deficiency, protein C deficiency, protein S deficiency, Factor V Leiden mutation, prothrombin 20210, and dysfibrinogenemia, among others.
Antithrombin deficiency, the most thrombogenic of all the inherited thrombophilias, also warrants antepartum anticoagulation as well as antithrombin infusions during labor and delivery.
Siemens will also feature the newest assays from their extensive test menu, including INNOVANCE D-Dimer, an aid in the diagnosis of deep vein thrombosis and INNOVANCE antithrombin tests an aid in the diagnosis of antithrombin deficiency and other coagulation disorders; Hemoglobin A1c to monitor patients with diabetes; CardioPhase hsCRP for cardiac risk assessment; Cystatin C for identifying kidney dysfunction; Berichrom Heparin calibrators and controls used with tests that monitor heparin levels; and new concentrated reagents that are diluted automatically on any ADVIA chemistry system on a per-test basis.
Patients with antithrombin deficiency or homozygous FVL need life long anticoagulation after a first VTE event due to high recurrence risk.
Atryn aims to prevent excessive blood clots in patients with a disorder known as hereditary antithrombin deficiency.
GTC, which already sells ATryn in Europe, is seeking approval to sell it in the United States as a treatment for hereditary antithrombin deficiency in patients undergoing surgery or childbirth.
We defined antithrombin deficiency as a decreased antithrombin activity (<650 IU/L), protein C deficiency as a decreased protein C antigen concentration (<650 IU/L) and/or activity (<650 IU/L), and protein S deficiency as decreased concentrations of total protein S antigen (<650 IU/L) and/or free protein S antigen (<650 IU/L), corresponding to plasma concentrations below the lower limit of their reference intervals (18).
14) Acquired or congenital antithrombin deficiency may reduce LMWH therapeutic efficacy.
In August 2006, ATryn, GTC's recombinant form of human antithrombin, was approved by the European Commission for use in patients with hereditary antithrombin deficiency undergoing surgical procedures.
The 14th edition adds entries on antithrombin deficiency and ovarian hyperstimulation syndrome.
The "anticoagulant" action of heparin requires the presence of antithrombin; thus, a clinical clue to diagnosis of antithrombin deficiency may be anticoagulation refractoriness to heparin.
rEVO Biologics announced today the results of a major retrospective study analysis of its pivotal phase 3 studies which demonstrate that pregnant patients with hereditary antithrombin deficiency (HD) benefit from ATryn Antithrombin (Recombinant) therapy to prevent venous thromboembolic events (VTE).