anti-müllerian hormone

(redirected from Antimullerian hormone)

mül·le·ri·an in·hib·it·ing sub·stance (MIS),

a 535-amino acid glycoprotein secreted by the Sertoli cells of the testis. It is related to inhibin.


A gene on chromosome 19p13.3 that encodes anti-Müllerian hormone, a member of the transforming growth factor-beta gene family, which mediates male sexual differentiation. AMH causes regression of Müllerian ducts, which would otherwise differentiate into the uterus and fallopian tubes.
Molecular pathology
AMH mutations result in persistent Müllerian duct syndrome.

müllerian inhibiting substance

A 59 kD glycosylated preproprotein of the TGF-beta family encoded by AMH on chromosome 19p13.3 and produced by Sertoli cells in the prepubertal testes, which promotes müllerian duct involution during normal male sexual differentiation. The lack of MIS results in persistent müllerian duct syndrome.

anti-müllerian hormone

the factor secreted by the Sertoli cells of the embryonic, developing testis that causes regression of the müllerian ducts, the primordia for the accessory sex glands of the female.
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References in periodicals archive ?
The patient's sister subsequently underwent clinical evaluation, including FMR1 testing and measurement of serum antimullerian hormone (AMH), an indicator of ovarian reserve (10).
3] Nonstandard abbreviations: TSH, thyroid-stimulating hormone; FSH, follicle-stimulating hormone; PCOS, polycystic ovary syndrome; DHEAS, dehydroepiandrosterone sulfate; POI, primary ovarian insufficiency; FX, fragile X; FMRP, FX mental retardation protein; UTR, untranslated region; FXS, FX syndrome; AMH, antimullerian hormone.
Antimullerian hormone predicts ovarian responsiveness, but not embryo quality or pregnancy, after in vitro fertilization or intracyoplasmic sperm injection.
A study by researchers at Brown University and Women & Infants Hospital shows that as the IVF cycle is beginning; a blood test for levels antimullerian hormone (AMH) can help predict the number of eggs that will be harvested.
Washington, June 10 (ANI): A new study has found that a blood test for levels of a hormone called AMH, or antimullerian hormone, at the beginning of the in vitro fertilization (IVF) cycle can help predict likelihood of pregnancy.
Menstruation resumed spontaneously 8 months later, and baseline levels of antimullerian hormone, which were previously undetectable (consistent with ovarian failure), were high--consistent with the presence of active follicles in an early stage of growth.
1-4] Depending on the severity of testicular dysgenesis, the antimullerian hormone (AMH) level may be low or undetectable in patients with abnormal testicular determination.