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Antimetabolite

   Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia 0.07 sec.
antimetabolite /an·ti·me·tab·o·lite/ (an?te-) (an?ti-me-tab´o-lit) a substance bearing a close structural resemblance to one required for normal physiological functioning, and exerting its effect by interfering with the utilization of the essential metabolite.
an·ti·me·tab·o·lite (nt-m-tb-lt, nt-)
n.
A substance that closely resembles an essential metabolite and competes with, interferes with, or replaces the metabolite in physiological reactions.

Antimetabolite
A drug that interferes with a cell's growth or ability to multiply.
Mentioned in: Chemotherapy

antimetabolite
a substance bearing a close structural resemblance to one required for normal physiological functioning, and exerting its effect by interfering with the utilization of the essential metabolite.

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Certain conventional chemotherapies, such as the antimetabolite gemcitabine, exert their anticancer activity at the S-phase of the cell cycle.
Surgeons began to find success with purine antimetabolites and with antilymphocytic globulin, developed by an upstart ex-football player named John Najarian.
He starts with Paul Ehrlich's antitreponemal arsenicals and ends with the antisense agents now in early clinical trials for the treatment of autoimmune diseases and cancer, covering in the process the development of antibacterial and antiviral agents, vaccines, antimetabolites, and hormone-based antineoplastic agents.
 
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