determinant /de·ter·mi·nant/ (de-ter´mĭ-nent) a factor that establishes the nature of an entity or event.
antigenic determinant,
determinant [de-ter´mĭ-nant]
antigenic determinant the structural component of an antigen molecule responsible for its specific interaction with antibody molecules elicited by the same or related antigen.
hidden determinant an antigenic determinant in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
| antigenic determinant n. Epitope. |
antigenic determinant,
a site on an antigen molecule to which an antibody molecule binds. Also called epitope.
determinant [de-ter´mĭ-nant]
a factor that establishes the nature of an entity or event.
antigenic determinant a site on the surface of an antigen molecule to which a single antibody molecule binds; generally an antigen has several or many different antigenic determinants and reacts with many different antibodies. Called also epitope.
Antigens contain antigenic determinants (epitopes) and antibodies contain antibody combining sites (paratopes). From Copstead and Banasik, 2000.
hidden determinant an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
immunogenic determinant the part of an immunogenic molecule that interacts with a helper T cell in triggering antibody production as opposed to the antigenic determinant or hapten, which interacts with B cells.
determinant
a factor that establishes or changes the nature of an entity or event. The factor may be environmental, be a part of the host or its defenses, be single or multiple and be immediate or remote.
allotypic determinant
an antigenic determinant which varies among members of the same species.
antigenic determinant
a structural component of an antigen against which immune responses are made and to which antibody or T cell receptor binds; an antigen such as a protein has many antigenic determinants. Called also epitope.
disease d's
factors which affect the occurrence or rate of ocurrence of a disease.
hidden determinant
an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
isotypic determinant
one that occurs in all individuals of the same species.
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