APX005M is a novel, humanised investigational monoclonal antibody designed to overcome the systemic immune suppression that typically affects cancer patients through activation of CD40, a co-stimulatory receptor on the antigen presenting cells
that is essential for activating both innate and adaptive immunity.
Binding of APX005M to CD40 on antigen presenting cells
initiates a multi-faceted immune response bringing multiple components to work in concert against cancer.
Found on antigen presenting cells
, such as dendritic cells, macrophages and B cells, CD40 is a key activator of the immune response.
The Advaxis Lm Technology utilizes live attenuated Listeria monocytogenes (Lm) bioengineered to produce and deliver tumor antigen/adjuvant fusion proteins within antigen presenting cells
with the goal of generating strong, T-cell-mediated immunity.
Moreover, the antigen itself should efficiently be delivered to the antigen presenting cells
along with a proper adjuvant which potentiates the T cell priming capabilities of them.
Activating naive T cells involves an antigen and ligands B71 (CD80) and B72 (CD86) on antigen presenting cells
His scientific contributions to the area of Mucosal Immunology include the demonstration of antigen presenting cells
in the gut-associated lymphoid tissues, unique functions of intra-epithelial lymphocytes, diversity of mucosal antigen sampling system and distinctive tissue genesis program for the nasopharynx- and tear duct-associated lymphoid tissues.
Given their potent immunomodulatory effects, further studies are urgently required to explore bystander effects of TQ on the professional antigen presenting cells
, including macrophages and dendritic cells, as well as its modulatory effects upon Th1- and Th2-mediated inflammatory immune diseases.
The Nottingham work has focused on the role of DC-SIGN, a receptor found on the surface of antigen presenting cells
The interaction of the Antigen Presenting Cell
and T-Cell also causes NF-KappaB activation in both cell types NF-KappaB activation is triggered in T-Cells by the engagement of the T cell receptor and the CD28 receptor with their ligands, MHC class II, and the costimulatory molecules CD80 and CD86 presented by Antigen Presenting Cells
CD4+ T cells are abundant in rheumatoid synovium, where they are found in proximity to antigen presenting cells
ocular antigen presenting cells
(APC), B cells, gamma delta ([gamma][delta]) T cells, NK T cells, [CD4.