antigen-presenting cell

(redirected from Antigen presenting cells)

antigen-presenting cell

a cell that can break down protein antigens into peptides and present the peptides, in conjunction with major HLA complex class II molecules, on the cell surface, where they can interact with T cell receptors. Macrophages are one type of antigen-presenting cell.

antigen-presenting cell

Abbreviation: APC
A cell that breaks down antigens and displays their fragments on surface receptors next to major histocompatibility complex molecules. This presentation is necessary for some T lymphocytes that are unable to recognize soluble antigens. Macrophages are the primary antigen-presenting cells, but B cells and dendritic cells also can act as APCs.
See: T cell; macrophage processing cell
See also: cell

antigen-presenting cell

A cell, such as a macrophage, a B cell or a dendritic cell, that presents processed antigenic peptides and MHC class II molecules to the T cell receptor on CD4 T cells.
References in periodicals archive ?
CD40, a receptor on the surface of antigen presenting cells of the immune system, plays a fundamental role in the activation of both innate and adaptive immune system mechanisms.
Production of antibodies is initiated by binding of B cell receptors (BCRs) to foreign antigens presented on the surfaces of antigen presenting cells.
DCT makes use of autologous or allogenic Antigen Presenting Cells (APCs) to stimulate the immune system to recognise and act against the tumors.
Given their potent immunomodulatory effects, further studies are urgently required to explore bystander effects of TQ on the professional antigen presenting cells, including macrophages and dendritic cells, as well as its modulatory effects upon Th1- and Th2-mediated inflammatory immune diseases.
The Nottingham work has focused on the role of DC-SIGN, a receptor found on the surface of antigen presenting cells.
pDCs produce type I interferons after exposure to conserved viral regions, and these cytokines stimulate the maturation of antigen presenting cells and the induction of antiviral CD8+ T cell, CD4+ T cell, NK cell and B cell responses.
The pathway to T-cell activation starts with antigen presentation using surface proteins from antigen presenting cells which cause calcium release from the sarcoplasmic reticulum via the [IP.
Specific topics include a survey of immunology, superantigens, antigen presenting cells, cell mediated immune defense, cytokines as molecular mediators, interleukens, interferons as viral inhibitors and immune response mediators, interferon signaling through Janus kinases and signal transducers and activators of transcription, flow cytometry, immunoassays, genetic engineering of antibody molecules, autoantibodies and autoimmunity, synovial mast cells in inflammatory arthritis and the molecular and cell biology of HIV/AIDS.
In subsequent experiments in cell culture, gold compounds were shown to render the immune system antigen presenting cells inactive, further strengthening this connection.
Virosome Biologicals' has proprietary intellectual property concerning the combination of an adjuvant (immune response stimulator) in the membrane that targets the virosomes specifically to antigen presenting cells or B cells.
T cell proliferation indirectly by targeting antigen presenting cells and modulating antigen-specific interactions.
Considered to be the most important professional antigen presenting cells, dendritic cells capture antigens and present them as peptide fragments to T cells, thereby regulating T cell dependent immunity.