CD40, a receptor on the surface of antigen presenting cells
of the immune system, plays a fundamental role in the activation of both innate and adaptive immune system mechanisms.
Production of antibodies is initiated by binding of B cell receptors (BCRs) to foreign antigens presented on the surfaces of antigen presenting cells
DCT makes use of autologous or allogenic Antigen Presenting Cells
(APCs) to stimulate the immune system to recognise and act against the tumors.
Given their potent immunomodulatory effects, further studies are urgently required to explore bystander effects of TQ on the professional antigen presenting cells
, including macrophages and dendritic cells, as well as its modulatory effects upon Th1- and Th2-mediated inflammatory immune diseases.
The Nottingham work has focused on the role of DC-SIGN, a receptor found on the surface of antigen presenting cells
pDCs produce type I interferons after exposure to conserved viral regions, and these cytokines stimulate the maturation of antigen presenting cells
and the induction of antiviral CD8+ T cell, CD4+ T cell, NK cell and B cell responses.
The pathway to T-cell activation starts with antigen presentation using surface proteins from antigen presenting cells
which cause calcium release from the sarcoplasmic reticulum via the [IP.
Specific topics include a survey of immunology, superantigens, antigen presenting cells
, cell mediated immune defense, cytokines as molecular mediators, interleukens, interferons as viral inhibitors and immune response mediators, interferon signaling through Janus kinases and signal transducers and activators of transcription, flow cytometry, immunoassays, genetic engineering of antibody molecules, autoantibodies and autoimmunity, synovial mast cells in inflammatory arthritis and the molecular and cell biology of HIV/AIDS.
In subsequent experiments in cell culture, gold compounds were shown to render the immune system antigen presenting cells
inactive, further strengthening this connection.
Virosome Biologicals' has proprietary intellectual property concerning the combination of an adjuvant (immune response stimulator) in the membrane that targets the virosomes specifically to antigen presenting cells
or B cells.
T cell proliferation indirectly by targeting antigen presenting cells
and modulating antigen-specific interactions.
Considered to be the most important professional antigen presenting cells
, dendritic cells capture antigens and present them as peptide fragments to T cells, thereby regulating T cell dependent immunity.