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cytotoxicity |
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cytotoxicity /cy·to·tox·ic·i·ty/ (si″to-tok-sis´ĭ-te) the degree to which an agent possesses a specific destructive action on certain cells or the possession of such action.cy´totoxic antibody-dependent cell-mediated cytotoxicity (ADCC) lysis of antibody-coated target cells by effector cells with cytolytic activity and Fc receptors. cell-mediated cytotoxicity cytolysis of a target cell by effector lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody-dependent or independent. cytotoxicity (sī´tōtoksis´itē), n a description of the extent of the destructive or killing capacity of an agent. Most often used to describe the character of immune activity or toxicity of certain drugs that limit the development of cancer cells. cytotoxicity destruction of cells; used to describe lysis of cells by immune mechanisms. See also antibody-dependent cell-mediated cytotoxicity (ADCC). How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Scientists at Xencor, a biotherapeutics company developing protein and antibody therapeutics, said the changes it made to the antibody Fc regions increased antibody effector functions such as activation of immune cells for tumor lysis, called Antibody-Dependent Cell-mediated Cytotoxicity (ADCC), by more than two orders of magnitude. |
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