monoclonal antibodies

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monoclonal antibodies

ANTIBODIES (immunoglobulins) produced by hybrid B lymphocyte tumours (myelomas). The type of antibodies produced depend on the selection of the B cell. These can be fused to cultured mouse, or even human, myeloma cells to form immortal tumours (hybridomas)-clones of cells that continue indefinitely to generate large quantities of the particular antibody produced by the B cell. The availability of quantities of almost any desired antibody has major diagnostic, therapeutic and research implications and monoclonal antibody production is one of the most important biotechnological advances of the century. Monoclonal antibodies can be made that will seek out and recognize cancers anywhere in the body, and this offers a number of intriguing possibilities for treatment. They are, however, less specific than had been initially thought, and can bind to molecules other than those intended. A serious accident occurred in a therapeutic trial in March 2206.

monoclonal antibodies

cloned (i.e. identical) antibodies

monoclonal

derived from a single cell; pertaining to a single clone.

monoclonal antibodies
identical immunoglobulin molecules formed by a single clone of plasma cells; may occur naturally in plasma cell myelomas or in vitro by the fusion of an antibody producing B lymphocyte with a non-antibody-producing myeloma B cell. The fused heterokaryon has the properties of immortality and production of a monoclonal antibody. For the most part, monoclonal antibodies are made in mouse systems.
monoclonal gammopathy
see monoclonal gammopathy.
References in periodicals archive ?
The market for antibody engineering is changing quickly due to novel technologies.
More recent developments are also included, such as antibody engineering and new assay configurations.
The 2nd Antibody Engineering Summit 2012 will discuss the policies, market, and R&D technologies, as well as arrange a GMP training session to interpret the latest standards and a factory tour to learn about the current technologies.
Xencor's XmAb antibody engineering technology enables small changes to the structure of monoclonal antibodies resulting in new mechanisms of therapeutic action.
27, 2015 /PRNewswire/ -- (Booth #3) -- Leading global genomics service provider, GENEWIZ, will discuss its antibody workflow solutions at the Seventh Annual PEGS Europe Protein & Antibody Engineering Summit, November 2-6 in Lisbon, Portugal.
Jallal mentioned, "The cutting-edge technologies developed by Spirogen and ADC Therapeutics complement MedImmune's innovative antibody engineering capabilities .
MAbstract is based on phage antibody-display libraries, subtraction and selection technology and antibody engineering technologies.
Henry's tremendous depth of experience in antibody engineering and therapeutic development has enabled him to make unique contributions to CytomX over the past year," said Sean McCarthy, D.
BioPh China gathers exhibitors on biotech, clinical trials, gene engineering, antibody engineering, cell cultures, bio-instruments and related products and technologies.
The cutting-edge technologies developed by Spirogen and ADC Therapeutics complement MedImmune s innovative antibody engineering capabilities, enabling us to accelerate antibody-drug conjugates into the clinic, said MedImmune executive vice president Bahija Jallal.
The issuance of this patent highlights the broad capabilities of antibody engineering technology at Protein Design," said Robert Kirkman, MD, Protein Design vice president, business development and corporate communications.
Ribovax owns two proprietary technology platforms in the field of antibody engineering that have already delivered patented therapeutic and diagnostic fully human monoclonal antibodies.