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Based on this encouraging observation, the next phase of CACAF is already underway, in which larger numbers of ablation-treated patients are being followed on or off antiarrhythmic drug therapy to learn whether medication is really necessary.
What's obsolete, he added, isn't antiarrhythmic drug therapy, but the process by which such drugs are developed and brought to market.
Section Two addresses safety pharmacology, including the concept of "repolarization reserve," safety challenges, and regulatory issues for the development of novel antiarrhythmic drugs.
As mentioned earlier, most AF patients are started on antiarrhythmic drugs, which are meant to return the heart to normal rhythm, maintain a healthy rhythm in the heart and/or slow the heart rate during an AF episode.
At 1-year follow-up, success among patients undergoing ablation was 10-fold greater than in those taking antiarrhythmic drugs (AADs), at 75% and 7%, respectively.
At that point it became less expensive and more effective than cardioversion and antiarrhythmic drugs.
those without recent myocardial infarction) or other antiarrhythmic drugs is uncertain, but at present, it is prudent to consider any 1C antiarrhythmic to have a significant risk in patients with structural heart disease.
While antiarrhythmic drugs are the frontline approach to treating AF, a minimally invasive procedure called catheter ablation can provide relief for people whose AF is resistant to drug treatment.
In our clinic at the Heraklion University Hospital in Greece, we are constantly studying atrial fibrillation and have a large series of patients who have been involved in various published studies comparing the antiarrhythmic drugs of classes I, II, III, and IV for all therapeutic targets (atrial fibrillation conversion, sinus rhythm maintenance, heart rate control).
Explore physician attitudes to the newer antiarrhythmic drugs, and the threats faced by existing and developmental products