Antiandrogens


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Antiandrogens

Drugs that inhibit the production of androgens.
References in periodicals archive ?
ADT was performed using the combination of a luteinizing hormone-releasing hormone agonist and a nonsteroidal antiandrogen, bicalutamide.
Clinical review: antiandrogens for the treatment of hirsutism: a systematic review and meta-analysis of randomized controlled Wals.
Spironolactone is an androgen receptor and 5a-reductase blocker, and its antiandrogen effects can improve acne.
OCPs, antiandrogens, metformin, eflomithine, and mechanical hair removal are recommended for hirsutism.
Although bicalutamide was discontinued due to watching antiandrogen withdrawal syndrome, the serum PSA level increased even more.
Antiandrogens block the androgen receptors competitively by producing a different conformational change avoiding participation of testosterone in the cellular process.
But it remains unclear whether that treatment is better because other studies testing the combination of radiation therapy and antiandrogens have used much lower doses of radiation, now known to be inadequate.
Antiandrogens are an option only for female patients and their use is limited.
For patients with earlier-stage prostate cancer, androgen deprivation therapy with LHRH agonists and first-generation antiandrogens remains the standard of care for suppressing testosterone levels and temporarily controlling the disease.
Widely used pesticides with previously unknown endocrine activity revealed as in vitro antiandrogens.
If the cancer is detected early, androgen ablation can be used for therapy either via chemical castration by use of antiandrogens, or surgical removal of the testicles, the major producers of androgens.
For women whose hidradenitis suppurativa flares before each period, tablets known as antiandrogens can be useful, for example, Dianette.