antinuclear antibody

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an·ti·nu·cle·ar an·ti·bod·y (ANA),

an antibody showing an affinity for nuclear antigens including DNA and found in the serum of a high proportion of patients with systemic lupus erythematosus, rheumatoid arthritis, and certain collagen diseases, and in some of their healthy relatives; as well as about 1% of otherwise healthy people. Different antinuclear antibodies generate distinctive patterns on immunofluorescence staining tests. These patterns have clinical relevance and reflect which nuclear constituents (autoantigens) are generative specific antibody responses.

antinuclear antibody

n. Abbr. ANA
Any of various antibodies that react with nuclear antigens such as nucleic acids and histones and are often present in the blood of people with systemic autoimmune rheumatic diseases.

antinuclear antibody (ANA)

[-no̅o̅′klē·ər]
an autoantibody directed against nuclear antigens. Antinuclear antibodies are found in the blood serum of patients with rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, polymyositis, scleroderma, Raynaud's disease, mixed connective tissue disease, and a number of nonrheumatic disorders ranging from lymphomas, leukemias, primary biliary cirrhosis, thyroiditis, chronic active hepatitis, and adverse drug reactions. The antibodies are often detected with an immunofluorescent assay technique.

antinuclear antibody

Any of a number of circulating antibodies directed against various antigens in the nucleus, including histone, double- and single-stranded DNA, and ribonucleoprotein. ANAs are often present in serum of patients with SLE and other connective tissue diseases.

antinuclear antibody

ANA Immunology Any of a number of circulating antibodies that are directed against various antigens in the nucleus, including histone, double- and single-stranded DNA, and ribonucleoprotein; ANAs are often present in serum of Pts with SLE and other connective tissue diseases. See Speckled pattern.

an·ti·nu·cle·ar an·ti·bod·y

, antinuclear factor (ANA, ANF) (an'tē-nū'klē-ăr an'ti-bod-ē, fak'tŏr)
An antibody showing an affinity for cell nuclei, demonstrated by exposing a cell substrate to the serum to be tested, followed by exposure to an antihuman-globulin serum; found in the serum of a high proportion of patients with systemic lupus erythematosus, rheumatoid arthritis, and certain collagen diseases, in some of their healthy relatives, and in about 1% of unaffected people.

antinuclear antibody,

n an autoantibody that reacts with nuclear material and is present in indivi-duals with autoimmune disorders; detectable by immunoflourescent assay technique.

an·ti·nu·cle·ar an·ti·bod·y

, antinuclear factor(ANA, ANF) (an'tē-nū'klē-ăr an'ti-bod-ē, fak'tŏr)
An antibody showing an affinity for cell nuclei, demonstrated by exposing a cell substrate to the serum to be tested, followed by exposure to an antihuman-globulin serum; found in the serum of a high proportion of patients with systemic lupus erythematosus, rheumatoid arthritis, and some collagen diseases.

antinuclear antibody

see antinuclear antibody.
References in periodicals archive ?
The findings of increased immunoglobulin levels, positive anti-nuclear antibody and positive anti-smooth muscle antibody in a chronic hepatitis patient indicate:
The other samples with anti-SSA antibodies gave a positive anti-nuclear antibody test.
Samples with antibodies to extractable nuclear antigens displayed the distinctive SSA pattern or an anti-nuclear antibody titer of 1:80 or higher.
ANTI-NUCLEAR ANTIBODY TESTING USING CONVENTIONAL HEp-2 SUBSTRATES
The anti-nuclear antibody test was also performed with HEp-2 substrates from Bio-Diagnostics Ltd.
5%) had an anti-nuclear antibody titer of 1:40 or higher, and 3489 samples had a anti-nuclear antibody titer of 1:80 or higher or displayed the distinctive SSA pattern.
One possibility suggested was a connective tissue disease and laboratory screening revealed high titer rheumatoid factor and anti-nuclear antibody with significant elevation in erythrocyte sedimentation rate.
Two of 11 criteria set by the ACR are related to anti-nuclear antibody detection (anti-nuclear antibodies; anti-ds-DNA or anti-sm or anti-phospholipid antibodies).
Serum concentrations of IgG anti-nuclear antibody were measured by an indirect immunofluorescence test (IFT) using Hep-2 cells (The Binding Site).
Anti-nuclear antibody testing with IFT on Hep-2 cells had a specificity of only 54%, whereas its sensitivity was 91%, thereby outperforming the sensitivities of the solid-phase ds-DNA-Ab assays (area under the ROC curve, 0.
The chapter on autoimmune disease and serology was not included in the current edition, and related topics such as anti-neutrophil cytoplasmic antibody, anti-nuclear antibody, dermatomyositis, Raynaud disease, and mixed connective tissue disease were not identified in the index.
40 Clinical summary Rheumatoid Rheumatoid arthritis arthritis, chest infection, atrial fibrillation Medication Prednisolone Ossopan, salazopyrine, ibuprofen, prednisolone, digoxin, bendrofluazide Rheumatoid factor (<20 3640 1280 kU/L) Anti-nuclear antibody Negative Diffuse 1:640 Serum gamma globulin Polyclonal Polyclonal Anti-thyroglobulin Negative 3900 antibody (<250 kU/L) Anti-microsomal antibody Negative Negative (<250 kU/L) Patients (all women) (b) 3 4 Age, years 82 82 FT4 (9.