antinuclear antibody

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an·ti·nu·cle·ar an·ti·bod·y (ANA),

an antibody showing an affinity for nuclear antigens including DNA and found in the serum of a high proportion of patients with systemic lupus erythematosus, rheumatoid arthritis, and certain collagen diseases, and in some of their healthy relatives; as well as about 1% of otherwise healthy people. Different antinuclear antibodies generate distinctive patterns on immunofluorescence staining tests. These patterns have clinical relevance and reflect which nuclear constituents (autoantigens) are generative specific antibody responses.

antinuclear antibody

n. Abbr. ANA
Any of various antibodies that react with nuclear antigens such as nucleic acids and histones and are often present in the blood of people with systemic autoimmune rheumatic diseases.

antinuclear antibody (ANA)

[-no̅o̅′klē·ər]
an autoantibody directed against nuclear antigens. Antinuclear antibodies are found in the blood serum of patients with rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, polymyositis, scleroderma, Raynaud's disease, mixed connective tissue disease, and a number of nonrheumatic disorders ranging from lymphomas, leukemias, primary biliary cirrhosis, thyroiditis, chronic active hepatitis, and adverse drug reactions. The antibodies are often detected with an immunofluorescent assay technique.

antinuclear antibody

Any of a number of circulating antibodies directed against various antigens in the nucleus, including histone, double- and single-stranded DNA, and ribonucleoprotein. ANAs are often present in serum of patients with SLE and other connective tissue diseases.

antinuclear antibody

ANA Immunology Any of a number of circulating antibodies that are directed against various antigens in the nucleus, including histone, double- and single-stranded DNA, and ribonucleoprotein; ANAs are often present in serum of Pts with SLE and other connective tissue diseases. See Speckled pattern.

an·ti·nu·cle·ar an·ti·bod·y

, antinuclear factor (ANA, ANF) (an'tē-nū'klē-ăr an'ti-bod-ē, fak'tŏr)
An antibody showing an affinity for cell nuclei, demonstrated by exposing a cell substrate to the serum to be tested, followed by exposure to an antihuman-globulin serum; found in the serum of a high proportion of patients with systemic lupus erythematosus, rheumatoid arthritis, and certain collagen diseases, in some of their healthy relatives, and in about 1% of unaffected people.

antinuclear antibody,

n an autoantibody that reacts with nuclear material and is present in indivi-duals with autoimmune disorders; detectable by immunoflourescent assay technique.

an·ti·nu·cle·ar an·ti·bod·y

, antinuclear factor(ANA, ANF) (an'tē-nū'klē-ăr an'ti-bod-ē, fak'tŏr)
An antibody showing an affinity for cell nuclei, demonstrated by exposing a cell substrate to the serum to be tested, followed by exposure to an antihuman-globulin serum; found in the serum of a high proportion of patients with systemic lupus erythematosus, rheumatoid arthritis, and some collagen diseases.

antinuclear antibody

see antinuclear antibody.
References in periodicals archive ?
Thus, the results of anti-nuclear antibody test not
21,22) She matched 4 of the 11 criteria of psychosis (neurologic disorder); positive anti-nuclear antibody test; thrombocytopenia and hypocomplementaemia with low C3 (haematologic disorder); and positive antiphospholipid antibody test (immunologic disorder).
Other pertinent laboratory examinations performed in consideration of the differential diagnoses for abnormal liver biochemistries were negative, including anti-hepatitis A virus antibody IgM, hepatitis B surface antigen, anti-hepatitis C virus antibody, anti-nuclear antibody, anti-smooth muscle antibody, anti-mitochondrial antibody, and anti-liver-kidney microsomal antibody.
Further inquiry revealed that she was diagnosed with SLE 18-years ago on the basis of polyarthralgias, facial rash, oral ulcers, alopecia, bicytopenias, positive anti-nuclear antibody (ANA) and anti-dsDNA antibody.
While anti-nuclear antibody levels were negative, the anti-mitochondrial antibody level was elevated at 26.
With the suspicion of a systemic vasculitic disease, autoimmune serology including serum rheumatoid factor, anti-nuclear antibody and anti-neutrophil cytoplasmic antibodies (ANCA) was studied and all were negative.
However, P-ANCA staining is also seen with antibodies to other neutrophil enzymes and with anti-nuclear antibodies (a neutrophil-specific anti-nuclear antibody or wrong reading because of the presence of anti-nuclear antibodies).
The findings of increased immunoglobulin levels, positive anti-nuclear antibody and positive anti-smooth muscle antibody in a chronic hepatitis patient indicate:
3]/[micro]L) 379 130-400 Erythrocyte sedimentation 21 0-20 rate (mm/h) C-reactive protein (mg/L) 10 0-5 Anti-nuclear antibody Negative Extractable nuclear antibodies Negative Immunofluorescence assay ANCA Negative Enzyme-linked immunosorbent Negative assay ANCA C3 (mg/dL) 156 90-180 C4 (mg/dL) 19 10-40 Hepatitis B surface antigen Negative Anti-Hepatitis B surface (IU/mL) Negative Anti-Hepatitis C virus Negative Anti-Human immunodeficiency virus Negative Fasting blood glucose (mg/dL) 95 70-110 Alanine transaminase (U/L) 15 <50 Aspartate transaminase (U/L) 19 <50 Gamma-glutamyl transaminase (U/L) 31 <55 Alkaline phosphatase (U/L) 70 <120 Total bilirubin (mg/dL) 0.