anti-mitochondrial antibody

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anti-mitochondrial antibody

Any antibody that reacts to various mitochondrial antigens; one such antigen is M2, which evokes the production of an AMA present in 90-95% of Pts with PBC, some of whom also have scleroderma; AMA is directed against the ATPase lipoprotein present on the inner mitochondrial membrane
References in periodicals archive ?
Among the patients with autoimmune diseases or with various intestinal diseases, 10 had values above the cutoff: 6 patients with type 1 AH [all positive for anti-smooth muscle antibodies (ASMAs)]; 2 patients with primary biliary cirrhosis (both positive for anti-mitochondrial antibodies and 1 positive for ASMAs), and 2 patients with multiple food intolerance.
However, anti-CA antibodies have also been detected in the absence of anti-mitochondrial antibodies in patients with PBC and ascites (16).
b) Hist, histones; ND, not done; Neg, negative; CTD, connective tissue disease; RA, rheumatoid arthritis; RF, rheumatoid factor; AMA, anti-mitochondrial antibodies.

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