antiandrogen

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androgen

 [an´dro-jen]
any steroid hormone that promotes male secondary sex characters. The two main androgens are androsterone and testosterone. Called also androgenic hormone. adj., adj androgen´ic. 

The androgenic hormones are internal endocrine secretions circulating in the bloodstream and manufactured mainly by the testes under stimulation from the pituitary gland. To a lesser extent, androgens are produced by the adrenal glands in both sexes, as well as by the ovaries in women. Thus women normally have a small percentage of male hormones, in the same way that men's bodies contain some female sex hormones, the estrogens. Male secondary sex characters include growth of the beard and deepening of the voice at puberty. Androgens also stimulate the growth of muscle and bones throughout the body and thus account in part for the greater strength and size of men as compared to women.
androgen insensitivity syndrome complete androgen resistance.

an·ti·an·dro·gen

(an'tē-an'drō-jen),
Any substance capable of preventing full expression of the biologic effects of androgenic hormones on responsive tissues, either by producing antagonistic effects on the target tissue, as estrogens do, or by merely inhibiting androgenic effects, such as by competing for binding sites at the cell surface.

antiandrogen

/an·ti·an·dro·gen/ (-an´dro-jen) any substance capable of inhibiting the biological effects of androgens.

antiandrogen

(ăn′tē-ăn′drə-jən, ăn′tī-)
n.
A substance that inhibits the biological effects of androgenic hormones.

antiandrogen

Endocrinology A hormone or other agent–eg, megestrol acetate, spironolactone, flutamide, nilutamide, and cimetidine, which interferes with androgen function by competitively inhibiting androgen binding to cognate receptors at the target organ and is either biologically inert or functionally very weak; these compounds are used to manage androgen-dependent CAs–♂ breast and prostate, hirsutism, acne

Antiandrogen

A substance that blocks the action of androgens, the hormones responsible for male characteristics. Used to treat prostate cancers that require male hormones for growth.
Mentioned in: Prostate Cancer

antiandrogen

any substance capable of inhibiting the biological effects of androgenic hormones.
References in periodicals archive ?
Combination with anti-androgens (MDV3100 or bicalutamide) showed much-improved inhibitory effect in growth assays compared to MDV3100 alone.
Five percent used steroidal anti-androgens with LHRH, despite worse survival demonstrated in an individual patient data meta-analysis showing inferior survival (hazard ratio 1.
Chlordane, once again, could cause lowered testosterone concentrations through its activity as an anti-androgen, whereas Aroclor could have this effect by causing an increase in aromatase activity.
Differences in androgen sensitivity due to genetic variations in the AR gene have been associated with hair loss and response to anti-androgen therapy.
HYG-440, a topical anti-androgen, is under study as a potential treatment for acne and androgenic alopecia.
NASDAQ: ARIA) today presented preclinical data on the investigational mTOR inhibitor, deforolimus, alone or in combination with the anti-androgen agent, bicalutamide, in models of prostate cancer.
The multi-center, randomized, double-blind clinical trial will compare oral deforolimus in combination with the anti-androgen drug bicalutamide (CASODEX([R])) against placebo and bicalutamide in men with asymptomatic, metastatic, androgen-independent prostate cancer.
Healthcare professionals in the EU must not use a combination of Xofigo with the anti-androgen Zytiga and prednisone/prednisolone, and should stop this combination in men currently treated with it and review the treatment for these patients.
Our study addresses this issue by extending data showing anti-androgen effects of analgesics (compounds found in ibuprofen) and suggests that such compounds may be involved in adult male reproductive problems.
Oric-101, discovered and tested by Oric's internal research team, was found to link GR to anti-androgen resistance in castration-resistant prostate cancer.
In the specific clinical scenario used in the study, the transgender actress was taking the anti-androgen hormone, spironolactone, for reducing masculinisation, along with the feminising hormone estradiol.
Patients on anti-androgen therapy such as spironolactone should discontinue the drug at least three months prior to conception.