anti-müllerian hormone

(redirected from Anti-Mullerian hormone)

mül·le·ri·an in·hib·it·ing sub·stance (MIS),

a 535-amino acid glycoprotein secreted by the Sertoli cells of the testis. It is related to inhibin.


A gene on chromosome 19p13.3 that encodes anti-Müllerian hormone, a member of the transforming growth factor-beta gene family, which mediates male sexual differentiation. AMH causes regression of Müllerian ducts, which would otherwise differentiate into the uterus and fallopian tubes.
Molecular pathology
AMH mutations result in persistent Müllerian duct syndrome.

müllerian inhibiting substance

A 59 kD glycosylated preproprotein of the TGF-beta family encoded by AMH on chromosome 19p13.3 and produced by Sertoli cells in the prepubertal testes, which promotes müllerian duct involution during normal male sexual differentiation. The lack of MIS results in persistent müllerian duct syndrome.

anti-müllerian hormone

the factor secreted by the Sertoli cells of the embryonic, developing testis that causes regression of the müllerian ducts, the primordia for the accessory sex glands of the female.
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References in periodicals archive ?
You also should test the serum anti-Mullerian hormone biomarker (readings above 8 are concerning) and look for two possible causes.
Objective: To evaluate the strength of anti-mullerian hormone in reflecting the stages of ovarian toxicity-induced by cyclophosphamide.
The predictive accuracy of anti-Mullerian hormone for live birth after assisted conception: a systematic review and meta-analysis of the literature.
The levels of anti-Mullerian hormone (AMH), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-a), and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were measured using enzyme-linked immunosorbent assay.
In patients with PCOS, ovarian levels of Anti-Mullerian Hormone (AMH) are also elevated, indicating the potential relevance of AMH for PCOS diagnosis and management.
DOR was defined as the presence of 2 of the following 3 criteria: 1) anti-Mullerian hormone [less than or equal to]1, 2) follicle-stimulating hormone [greater than or equal to]10, and 3) bilateral antral follicle count [less than or equal to]6.
Its individualised dosing regimen is based on a woman's serum anti-Mullerian hormone level and her body weight.
Nowadays, more direct ovarian markers are available to measure ovarian function or reserve inhibin B, AFC (Antral Follicle Count) and anti-Mullerian hormone (AMH).
Control of Primordial Follicle Recruitment by Anti-Mullerian Hormone in the Mouse Ovary 1.
Laboratory findings suggestive of GCT include elevated inhibin-A, inhibin-B, anti-Mullerian hormone (AMH), and CA-125.
BOSTON -- Anti-Mullerian hormone levels strongly predict the rate of perimenopausal loss of bone mineral density and might help identify women who need early intervention to prevent future osteoporotic fractures, according to data from a review of 474 perimenopausal women that was presented at the annual meeting of the Endocrine Society.
Serum concentrations of prolactin (PRL), luteinizing hormone (LH), total testosterone (TT), sexhormone-binding globulin (SHBG), free-testosterone (FT), dehydroepiandrosterone-sulfate (DHEA-S), anti-Mullerian hormone (AMH), C-peptide, fasting glucose, and fasting insulin levels were assessed within the first 5 days of the menstrual cycle.

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