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anthracycline |
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anthracycline /an·thra·cy·cline/ (-si´klēn) a class of antineoplastic antibiotics produced by Streptomyces peucetius and S. coeruleorubidus, including daunomycin and doxorubicin. anthracycline a class of antibiotics isolated from cultures of Streptomyces peucetius; it includes the antineoplastic agents daunomycin and doxorubicin. See also anthracycline antibiotic. anthracycline Oncology A chemotherapeutic used in leukemia to prevent cell division Adverse effects Dose-dependent stomatitis, N&V and BM suppression which 'maxes' at ± 10 days; alopecia is normal; extravasation at IV
injection site causes severe, protracted ulcers and necrosis. See Chemotherapy, Daunorubicin, Doxorubicin, Idarubicin. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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2) Children at high risk for relapse receive more intense chemotherapy, particularly with steroids and anthracyclines. The altered expression of mitochondrial genes might be expected based on a recent study that demonstrated that anthracyclines, such as DOX, impair cellular respiration (Souid et al. Clinicians should be aware that the 3 approved mono-chemotherapy agents for KS (2 liposomal anthracyclines and paclitaxel) have predictable overlapping toxicities with the various antiretroviral drugs. |
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