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anthracycline
(redirected from Anthracyclines)

   Also found in: Wikipedia 0.07 sec.
anthracycline /an·thra·cy·cline/ (-si´klēn) a class of antineoplastic antibiotics produced by Streptomyces peucetius and S. coeruleorubidus, including daunomycin and doxorubicin.
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Anthracycline. For daunorubicin, R1=sbondCH3; for doxorubicin, R1=sbondCHOH.

anthracycline
a class of antibiotics isolated from cultures of Streptomyces peucetius; it includes the antineoplastic agents daunomycin and doxorubicin. See also anthracycline antibiotic.

anthracycline
Oncology A chemotherapeutic used in leukemia to prevent cell division Adverse effects Dose-dependent stomatitis, N&V and BM suppression which 'maxes' at ± 10 days; alopecia is normal; extravasation at IV injection site causes severe, protracted ulcers and necrosis. See Chemotherapy, Daunorubicin, Doxorubicin, Idarubicin.


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2) Children at high risk for relapse receive more intense chemotherapy, particularly with steroids and anthracyclines.
The altered expression of mitochondrial genes might be expected based on a recent study that demonstrated that anthracyclines, such as DOX, impair cellular respiration (Souid et al.
Clinicians should be aware that the 3 approved mono-chemotherapy agents for KS (2 liposomal anthracyclines and paclitaxel) have predictable overlapping toxicities with the various antiretroviral drugs.
 
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