ANXA2

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ANXA2

A gene on chromosome 15q22.2 that encodes annexin 2, a calcium-regulated membrane-binding protein that controls cell growth and signal transduction pathways; it also acts as an autocrine factor, which increases osteoclast formation and bone resorption.
References in periodicals archive ?
Subsequent studies have found that chlorotoxin peptides and engineered variants may bind and potentially be internalized by malignant cells via the annexin A2 complex.
13) (Muscle-type aldolase) 145 Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) 146 Annexin A2 (Annexin II) (Lipocortin II) (Calpactin I heavy chain) 147 Aspartate aminotransferase, mitochondrial precursor (EC 2.
They have found that the degradation by PCSK9 of the LDLR receptor, which is responsible for removing the bad cholesterol (LDL-cholesterol) from the bloodstream, could be inhibited by a third protein, annexin A2.
By performing a series of biochemical experiments, we discovered that annexin A2 binds strongly to PCSK9 and inhibits its function," said GaE[umlaut]tan Mayer, the article's first author.
Circulating Gc-globulin colocalizes with both CD44 and annexin A2 receptors on the cell surface and may use both pathways to enhance C5a-mediated chemotaxis (33).
For cell--cell interaction genes and genes involved in signal transduction, marked increases occurred in annexin A2 (48-fold), nidogen 1 (50-fold), E-cadherin (11-fold), and [beta]-catenin (7-fold) in arsenic-induced HCC.
Preclinical studies confirm that TM601 targets and binds to Annexin A2, a receptor expressed on a wide range of tumor cells but not on normal, healthy cells.
Subsequent studies have found the peptide and engineered variants can bind be internalized by malignant cells via the annexin A2 complex.
Is annexin A2 CYS8 the sole requirement for this association?
The other calcium-binding proteins in this cluster, annexin A2 (Anxa2) and annexin A6 (Anxa6), are not reported to have such a relationship to fibrosis, but as calcium-binding proteins, and it is interesting to observe that they are increased in expression in the same manner as calcyclin.
Data presented at ARVO demonstrate that TM601 binds to annexin A2 and causes new blood vessel regression-
Poster # 1164/D1126 is titled, "TM601, a Peptide That Binds Annexin A2, Causes Regression of Choroidal Neovascularization (CNV)," and will be presented on Sunday, May 3, 2009 from 2:45-4:30pm EDT.